Changes to This Summary (12/19/2008)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Colon Cancer Genes
Added text to state that patients with juvenile polyposis syndrome have been reported to have large genomic deletions in BMPR1A and SMAD4, and rarely, mutations in both of the PTEN and BMPR1A genes, or both of the PTEN and ENG genes (cited van Hattem et al. and Sweet et al. as references 61 and 62, respectively).
Major Genetic Syndromes
Added text to describe genetic testing techniques.
Added text to state that in a prospective study of patients with FAP undergoing surveillance with esophagogastroduodenoscopy, fundic gland polyps were detected in 88% of the patients; low-grade dysplasia was detected in 38% of these patients, whereas high-grade dysplasia was detected in 3% of these patients (cited Bianchi et al. as reference 53).
Added South et al. as reference 190.
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