Genetics of Colorectal Cancer - National Cancer Institute

Table 7C. Summary of Studies Evaluating Interest in or Intention to Have Genetic Counseling and Testing for Familial Adenomatous Polyposis (FAP)^a

Study Population N^b Interest or Intention in GC or GT^c

FAP-affected individuals [16] 25 60% prenatal GT interest; 18% would consider aborting fetus if mutation was found

FAP-affected individuals [17] 62 65% prenatal GT interest; 24% would consider aborting fetus if mutation was found; 94% GT interest at birth

GC = genetic counseling; GT = genetic testing.

^aBoth studies used a cross-sectional design and were conducted in the United Kingdom.[16,17]

^bIndicates number of participants older than 18 y, unless otherwise specified.

^cType of genetic test not specified.

References

Burn J, Chapman P, Delhanty J, et al.: The UK Northern region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium, and DNA markers in risk calculations. J Med Genet 28 (5): 289-96, 1991. [PUBMED Abstract]
Whitelaw S, Northover JM, Hodgson SV: Attitudes to predictive DNA testing in familial adenomatous polyposis. J Med Genet 33 (7): 540-3, 1996. [PUBMED Abstract]