Study Population	Nb	Interest or Intention in GC or GTc
Unaffectedd FDRs of CRC patients undergoing treatment [11]	45	51% definite GT intention; 31% probable
CRC patients and unaffected individuals undergoing Lynch syndrome GC [15]	31 CRCs; 34 unaffected	Precounseling: 100% (29). GT intention among CRCs who were aware of GT. 92% (30) GT intention among unaffecteds who were aware of GT
		Post-counseling: no one decided against testing, but 5 unaffecteds (18%); 1 CRC undecided
CRC patients, unaffected FDRs, and age/gender-matched controls recruited from HCCR and driver’s license/Medicare records [9]	105	If relative is a carrier: GT intention for 67% of CRCs; 75% of FDRs; 60% of controls
		If insurance covers cost: GT intention for 17% of CRCs; 75% of FDRs; 40% of controls

CRC = colorectal cancer; FDR = first-degree relative; GC = genetic counseling; GT = genetic testing; HCCR = hereditary colon cancer registry.

aAll studies used a cross-sectional design, with the exception of one study, which used focus groups.[9] All studies were conducted in the United States, with the exception of one German study.[15]

bIndicates number of participants older than 18 y, unless otherwise specified.

cType of genetic test not specified.

dUnaffected = no previous diagnosis of colorectal cancer.

References

9. Ramsey SD, Wilson S, Spencer A, et al.: Attitudes towards genetic screening for predisposition to colon cancer among cancer patients, their relatives and members of the community. Results of focus group interviews. Community Genet 6 (1): 29-36, 2003.  [PUBMED Abstract]
   
   
11. Lerman C, Marshall J, Audrain J, et al.: Genetic testing for colon cancer susceptibility: Anticipated reactions of patients and challenges to providers. Int J Cancer 69 (1): 58-61, 1996.  [PUBMED Abstract]
    
    
15. Keller M, Jost R, Haunstetter CM, et al.: Comprehensive genetic counseling for families at risk for HNPCC: impact on distress and perceptions. Genet Test 6 (4): 291-302, 2002.  [PUBMED Abstract]