 |
|
|
Table 4. Extracolonic Tumor Risks in Familial Adenomatous Polyposis
|
Malignancy
|
Relative Risk
|
Absolute Lifetime Risk (%)
|
| Desmoid |
852.0 |
15.0 |
| Duodenum |
330.8 |
3.0–5.0 |
| Thyroid |
7.6 |
2.0 |
| Brain |
7.0 |
2.0 |
| Ampullary |
123.7 |
1.7 |
| Pancreas |
4.5 |
1.7 |
| Hepatoblastoma |
847.0 |
1.6 |
| Gastric |
— |
0.6a |
|
Adapted from Giardiello et al.,[10] Jagelman et al.,[11] Sturt et al.,[12] Lynch et al.,[13] Bülow et al.,[14] and Galiatsatos et al.[15]
|
|
aThe Leeds Castle Polyposis Group.
|
References
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Giardiello FM, Offerhaus JG: Phenotype and cancer risk of various polyposis syndromes. Eur J Cancer 31A (7-8): 1085-7, 1995 Jul-Aug.
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Jagelman DG, DeCosse JJ, Bussey HJ: Upper gastrointestinal cancer in familial adenomatous polyposis. Lancet 1 (8595): 1149-51, 1988.
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Sturt NJ, Gallagher MC, Bassett P, et al.: Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. Gut 53 (12): 1832-6, 2004.
[PUBMED Abstract]
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Lynch HT, Fitzgibbons R Jr: Surgery, desmoid tumors, and familial adenomatous polyposis: case report and literature review. Am J Gastroenterol 91 (12): 2598-601, 1996.
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Bülow S, Björk J, Christensen IJ, et al.: Duodenal adenomatosis in familial adenomatous polyposis. Gut 53 (3): 381-6, 2004.
[PUBMED Abstract]
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Galiatsatos P, Foulkes WD: Familial adenomatous polyposis. Am J Gastroenterol 101 (2): 385-98, 2006.
[PUBMED Abstract]
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