Molecular Interaction Networks to Dissect Master Regulators of Malignant Transformations (NIH-Only)
 


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Air date: Tuesday, February 26, 2008, 8:00:00 AM
Category: NCI CCR Grand Rounds (NIH Only)
Description: Center for Cancer Research - National Cancer Institute Grand Rounds

Dr. Andrea Califano received the Laurea in Physics (magna cum laude) on the study of the chaotic behavior in high-dimensional dynamical systems from the University of Florence, Italy, in 1985. He was first a Research Associate at the Istituto Nazionale di Ottica in Florence, Italy and then a postdoc in the Information Mechanic Group at the Massachusetts Institute of Technology, Cambridge. From 1986 to 1990, he was a Research Staff Member in the Exploratory Computer Vision Group at the IBM T.J. Watson Research Center. In 1990 Dr. Califano started the IBM research initiative in Computational Biology, which culminated with the creation of the IBM Computational Biology Center in 1997, a worldwide organization that he directed until his departure. The center’s activities spanned bioinformatics, chemo-informatics, protein structure prediction, and the modeling/simulation of complex biological system. In 2000 he co-founded First Genetic Trust, Inc, a privately funded startup company, as Executive VP and Chief Technology Officer. Under his leadership, FGT built the first GxP compliant, integrated clinical-genomic trial management system and conducted several large scale Pharmacogenomic studies. Finally, in 2003, he was appointed Professor of Biomedical Informatics at Columbia University, where he is currently Director of the Center for the Multiscale Analysis of Genetic Networks (MAGNet) – one of seven NIH-funded National Centers for Biomedical Computing, – Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center (HICCC), and co-Director of the Center for Computational Biology and Bioinformatics (C2B2). His scientific interests lay in the investigation of Systems Biology, using a variety of physics- and knowledge-based methods. Since 1998 he has been especially active in the development of integrative methodologies for the dissection of cancer phenotypes. His lab has pioneered a wide range of methodologies for the reverse engineering and biochemical validation of genome-wide gene regulatory networks in human cells – including transcriptional, post-transcriptional, and post-translational interactions – and in their use for the dissection of physiologic and pathologic phenotypes.

The primary educational objective of these seminars is to provide new information, ideas, and discussion about timely areas of research with impact on the field of oncology. A secondary educational objective is to elicit participation by individuals from all divisions of the intramural NCI, and thus facilitate more interactions among investigators and groups in the NCI.
Author: Dr. Andrea Califano, Columbia University
Runtime: 01:12:24
CIT File ID: 14316
CIT Live ID: 6585
Permanent link: http://videocast.nih.gov/launch.asp?14316