Protocol Number: 01-DK-0249

Title:

Ingested Interferon-Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

Number:

01-DK-0249

Summary:

This study will see if interferon-alpha given early in the disease can stop or slow the immune attack on insulin-producing cells. In addition, the study will examine the safety and efficacy of interferon-alpha (given by mouth) to protect beta cell function. Patients between 3 and 25 years of age with Type 1 Diabetes Mellitus less then six weeks may be eligible for this study. All study-related tests and medications at the NIH Clinical Center are provided at no cost.

Sponsoring Institute:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Diabetes

Immunotherapy

Study Drug

Recruitment Keyword(s):

Insulin Dependent Diabetes

Diabetes

Diabetes Mellitus

TIBM

Condition(s):

Insulin-Dependent Diabetes Mellitus

Investigational Drug(s):

Oral Interferon-Alpha

Investigational Device(s):

None

Interventions:

Drug: Oral Interferon-Alpha

Supporting Site:

National Institute of Diabetes and Digestive and Kidney Diseases

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

The pathogenesis of insulin-dependent diabetes mellitus

Type I diabetes mellitus A chronic autoimmune disease

Ingested interferon alpha suppresses type I diabetes in non-obese diabetic mice

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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