| Agent Name |
Allyl chloride |
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| CAS Number |
107-05-1 |
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| Formula |
C3-H5-Cl |
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| Major Category |
Solvents |
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| Synonyms |
3-Chloropropene; 1-Chloro-2-propene; 3-Chloro-1-propene; 3-Chloropropylene; Chloroallylene; [NIOSH] |
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| Category |
Chlorinated Solvents |
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| Description |
Colorless, brown, yellow, or purple liquid with a pungent, unpleasant odor; [NIOSH] |
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| Sources/Uses |
Used in the manufacture of organic chemicals; [ACGIH] |
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| Comments |
Liquid causes first degree burns on short exposure; [CHRIS] Corrosive to skin; [Quick CPC] Probably a mild eye irritant; [CHEMINFO] Experimental animals suffer no apparent adverse effects after being exposed to 3 ppm, 7 hours/day, 5 days/week for 6 months. In acute inhalation exposure studies at concentrations varying from 200 to 2000 ppm, dose dependent kidney damage is observed in rat and mice; Kidney and peripheral nerve injury is observed in mice given 300-500 mg/kg orally 3 times a week for 2-17 weeks. Peripheral neuropathy was reported in 53% of factory workers chronically exposed to allyl chloride. [ACGIH] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
1 ppm |
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| STEL (ACGIH) |
2 ppm |
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| PEL (OSHA) |
1 ppm |
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| IDLH (NIOSH) |
250 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that a 1-hour exposure to 300 ppm might cause serious effects. |
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| Vapor Pressure |
295 mm Hg |
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| Odor Threshold Low |
0.48 ppm |
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| Odor Threshold High |
5.9 ppm |
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| Lethal Concentration |
LC50 (rats) = 11,000 mg/m3/2H |
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| Explanatory Notes |
Odor threshold from AIHA; Flash point equals -25 deg F; [CHEMINFO] |
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| Half Life |
No reports found; [TDR, p. 67] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Neurotoxin |
Sensorimotor Neuropathy |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ALLYL CHLORIDE
|
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