| Agent Name |
4-Aminopyridine |
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| Alternative Name |
Fampridine |
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| CAS Number |
504-24-5 |
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| Formula |
C5-H6-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
4-Pyridinamine; 4-Pyridylamine; p-Aminopyridine; gamma-Aminopyridine; Avitrol 200; Fampridine; 4-AP; Amino-4 pyridine; Avitrol [ChemIDplus] |
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| Category |
Pyridines |
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| Description |
White crystals; [CAMEO] Formulated as grain bait or powder concentrate; [EXTOXNET] |
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| Sources/Uses |
Used as a chemical intermediate, a bird repellant, and a medication; [HSDB] A potassium channel blocker that is used primarily in research, but also in medicine to treat Lambert-Eaton syndrome and multiple sclerosis; [ChemiIDplus] Used as an avicide, an intermediate, and textile dye fixative; [CAMEO] |
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| Comments |
"Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias." [CAMEO] Effective bird repellant as flock is frightened by distress of poisoned birds; Avitrol is a central nervous system stimulant, and as little as 60 mg causes severe poisoning in adult humans. It is readily absorbed through the skin. Symptoms of poisoning include thirst, dizziness, weakness, sweating, toxic psychosis, tremors, and seizures. Avitrol can also cause methemoglobinemia. It is an eye irritant. [EXTOXNET] |
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| Reference Link |
EXTOXNET PIP - 4-AMINOPYRIDINE |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
0.00034 mm Hg |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Dermatotoxin |
Skin Burns |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Links to Other NLM Databases |
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