| Agent Name |
Isophorone diamine |
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| CAS Number |
2855-13-2 |
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| Formula |
C10-H22-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-3-aminomethyl-3,5,5-trimethyl cyclohexane; 3-Aminomethyl-3,5,5-trimethyl cyclohexylamine; Cyclohexanemethanamine,5-amino-1,3,3-trimethyl-; ISOPHORONEDIAMINE (CIS- AND TRANS- MIXTURE); ISOPHORONEDIAMINE; [ChemFinder] IPD; IPDA; UN2289; |
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| Category |
Amines, Heterocyclic |
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| Description |
Colourless to pale yellow liquid with an ammonia-like odor; [CHEMINFO] |
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| Sources/Uses |
Used to manufacture isophorone diisocyanate; [HSDB] |
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| Comments |
If inhaled, it can provoke coughing and nausea. [CHRIS] An epoxy resin hardener and suspected cause of occupational asthma, isophorone diamine is one component of mixtures causing occupational asthma in two separate documented cases: (1) [Occupational asthma due to EPO 60. Lambourn EM, Hayes JP, McAllister WA, Taylor AJ. Br J Ind Med 1992 Apr;49(4):294-5]; and (2) [Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine. Aleva RM et al. Am Rev Respir Dis 1992 May;145(5):1217-8] It can cause pulmonary edema after heavy inhalation exposure and is corrosive to skin; a potential skin sensitizer. [ICSC] |
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| Reference Link |
Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
0.01 mm Hg |
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| Explanatory Notes |
Flash point =112 deg C; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Adverse Effects |
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| Asthma |
Yes |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ISOPHORONE DIAMINE
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