| Agent Name |
Triorthocresyl phosphate |
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| CAS Number |
78-30-8 |
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| Formula |
C21-H21-O4-P |
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| Major Category |
Other Classes |
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| Synonyms |
TCP; TOCP; Tri-o-cresyl phosphate; Tri-o-cresyl ester of phosphoric acid; [NIOSH] |
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| Category |
Phosphorus Compounds |
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| Description |
Colorless to pale-yellow, odorless liquid or solid (below 52 degrees F). [NIOSH] |
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| Sources/Uses |
Used as a flame retardant, plasticizer, lubricant, additive to gasoline and hydraulic fluids, and intermediate for pharmaceuticals. [ACGIH] |
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| Comments |
Ingested TOCP was the cause of "ginger jake paralysis" or "jake leg," a form of organophosphate induced delayed neuropathy (OPIDN). The minimum paralytic dose in humans by ingestion is approximately 10 to 30 mg/kg. Reported adverse effects after occupational exposure include reduced plasma cholinesterase activity and peripheral neuropathy. No neurological abnormalities were found after careful examination of workers exposed over several months to hydraulic fluid containing 21% TOCP and air concentrations of 1.5 mg/m3. The compound is transformed in the liver to a metabolite responsible for cholinesterase inhibition and axon degeneration. [ACGIH] |
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| Exposure Assessment |
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| BEI |
Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.1 mg/m3 |
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| PEL (OSHA) |
0.1 mg/m3 |
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| IDLH (NIOSH) |
40 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Human data: It has been reported that serious paralysis has been produced by an oral dose of about 6.6 mg/kg [Deichmann and Gerarde 1969] and that the probable lethal dose is greater than 28 mg/kg [Patty 1963]. [Note: Oral doses of 6.5 or 28 mg/kg are equivalent to a 70�kg worker being exposed to about 300 or 1,300 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.] |
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| Vapor Pressure |
2 x 10 -05 mm Hg |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Neurotoxin |
Motor Neuropathy |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TRI-O-CRESYL PHOSPHATE
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