| Agent Name |
o-Anisidine |
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| CAS Number |
90-04-0 |
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| Formula |
C7-H9-N-O |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-2-methoxybenzene; 2-Aminoanisole; 2-Anisidine; 2-Methoxy-1-aminobenzene; 2-Methoxyaniline; 2-Methoxybenzenamine; Benzenamine, 2-methoxy-; o-Aminoanisole; o-Anisylamine; o-Methoxyaniline; o-Methoxyphenylamine; ortho-Aminoanisole; ortho-Methoxyaniline; ortho-Methoxyphenylamine; [ChemIDplus] UN2431 |
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| Category |
Amines, Aromatic |
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| Description |
Red or yellow, oily liquid with an amine-like odor; Note: A solid below 41 degrees F; [NIOSH] |
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| Sources/Uses |
Used in the synthesis of azo dyes and guaiacol; [ACGIH] |
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| Comments |
Hematologic changes, anemia, nephrotoxicity, and bladder cancer occur in animal studies. Workers exposed at 0.4 ppm for 3.5 hours/day for six months did not develop anemia, but did have methemoglobinemia and Heinz bodies as well as complaints of headache and vertigo. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Evidence of liver injury in high-dose feeding studies of rats; [HSDB] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.5 mg/m3 |
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| PEL (OSHA) |
0.5 mg/m3 |
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| IDLH (NIOSH) |
50 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH. |
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| Vapor Pressure |
0.08 mm Hg |
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| Explanatory Notes |
Flash point = 118 deg C; |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: O-ANISIDINE
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