| Agent Name |
p-Phenylenediamine |
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| CAS Number |
106-50-3 |
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| Formula |
C6-H8-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1,4-Diaminobenzene; 1,4-Phenylenediamine; 4-Aminoaniline; 6PPD; AI3-00710; BASF ursol D; Benzofur D; C.I. 76060; C.I. Developer 13; C.I. Oxidation Base 10; CI 76060; CI Developer 13; CI Oxidation Base 10; Developer 13; Developer PF; Durafur Black R; FUR Brown 41866; Fenylenodwuamina [Polish]; Fouramine D; Fourrine 1; Fourrine D; Fur Black 41866; Fur Black 41867; Fur Yellow; Furro D; Futramine D; Nako H; Orsin; Oxidation Base 10; PARA; Paraphenylen-diamine; Paraphenylenediamine; Pelagol D; Pelagol DR; Pelagol Grey D; Peltol D; Phenylenediamine; Renal PF; Rodol D; Santoflex IC; Santoflex LC; Tertral D; USAF EK-394; Ursol D; Vulkanox 4020; Zoba Black D; p-Aminoaniline; p-Benzenediamine; p-Diaminobenzene; p-Fenylendiamin [Czech]; p-Phenyldiamine; p-Phenylenediamine; UN1673; [ChemIDplus] |
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| Category |
Amines, Aromatic |
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| Description |
White to slightly red, crystalline solid; [NIOSH] |
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| Sources/Uses |
Used to dye hair and fur; also used to develop photographs and to synthesize other organic compounds; [ACGIH] Occupational asthma reported in fur dyers; [Malo] Allergic contact dermatitis in hairdressers, mechanics, printers, and textile workers; [Marks] |
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| Comments |
An important dye used for permanent hair coloring, the dye itself (but not the dyed hair) can cause allergic contact dermatitis. [Marks, p. 111] Immunologic contact urticaria documented; [Kanerva 2004, p. 102] In animal experiments, intraperitoneal injections induce methemoglobinemia, and chronic feeding causes fatty degeneration of the liver. Liver injury after occupational exposure has been reported. [ACGIH] Potential adverse effects include asthma, allergic contact dermatitis, methemoglobinemia, and kidney injury; [ICSC] |
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| Reference Link |
Allergic contact dermatitis on a violinist's neck from para-phenylenediamine in a chin rest stain |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
0.1 mg/m3 |
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| PEL (OSHA) |
0.1 mg/m3 |
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| MAK |
0.1 mg/m3, inhalable fraction |
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| IDLH (NIOSH) |
25 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for p�phenylene diamine. Therefore, based on health considerations and acute oral toxicity data in animals [Burnett et al. 1977; Hanzlik 1923; Lloyd et al. 1977], a value of about 50 mg/m3 would have been appropriate. However, the revised IDLH for p�phenylene diamine is 25 mg/m3 based on the concentration recommended originally in the Standards Completion Program for deciding when the "most protective" respirators should be used. Because sensitized workers may be affected by concentrations far below occupational exposure limits, exacerbation of asthma cannot be used to set an IDLH. |
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| Vapor Pressure |
0.005 mm Hg |
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| Lethal Concentration |
LC50 (rats) = 920 mg/m3/4H |
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| Explanatory Notes |
Flash point = 311 deg F; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Adverse Effects |
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| Asthma |
Yes |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,4-BENZENEDIAMINE
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