| Agent Name |
Phenylhydrazine |
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| CAS Number |
100-63-0 |
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| Formula |
C6-H8-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
Fenilidrazina [Italian]; Fenylhydrazine [Dutch]; Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Hydrazobenzene; Monophenylhydrazine; Phenylhydrazin [German]; Phenylhydrazine; [ChemIDplus] UN2572 |
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| Category |
Hydrazines |
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| Description |
Colorless to pale-yellow liquid or solid (below 67 degrees F) with a faint, aromatic odor; [NIOSH] |
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| Sources/Uses |
Used in the synthesis of dyes and pharmaceuticals; [ACGIH] |
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| Comments |
Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization; [ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure; [CHRIS] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.1 ppm |
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| PEL (OSHA) |
5 ppm |
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| IDLH (NIOSH) |
15 ppm |
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| Excerpts from Documentation for IDLHs |
No data on acute or chronic inhalation toxicity are available on which to base the IDLH. Systemic effects described by Patty [1963] were caused by chronic exposures from oral dosing. NIOSH [1976] cited a rat oral LD50 of 188 mg/kg [Ekshtat 1965] which provides a calculated estimate of 1,300 mg/m3 (295 ppm) for the IDLH. |
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| Vapor Pressure |
0.02 mm Hg |
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| Lethal Concentration |
LC50 (rats) = 2,610 mg/m3 |
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| Explanatory Notes |
Flash point = 88 deg C; |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Anemia |
Anemia, Hemolytic |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: PHENYLHYDRAZINE
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