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Selected Publications:
- Yasgar A, et al. Compound Management for Quantitative High-Throughput Screening. JALA. In press.
- Simeonov A, et al. Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Anal Biochem. In Press
- Simeonov A, et al. Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay Drug Dev Technol. 2007 Dec;5(6):815-24.
- Auld, et al. Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods Enzymol. 2006;414:566-89.
- Inglese, et al. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. Epub 2006 Jul 24.
- Foss AA, et al. Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants. J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):78-85. Epub 2006 Apr 25.
2005-Present:Research Associate, National Institutes of Health, NIH Chemical Genomics Center, Washington, DC
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Evaluate new technologies resulting in proposal for innovative screening processes and novel assay formats
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Develop and optimize cell-based assays for fully automated robotic screening
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Operate liquid dispensing systems and multimodal detectors/plate readers
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Write technical reports and prepare manuscripts in collaboration with investigators
2001-2005:Senior Associate Scientist, Pfizer Inc., Pfizer Global Research and Development, Pharmacokinetics, Dynamics, and Metabolism, Groton, CT
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In vivo animal pharmacokinetic studies including animal handling, dosing, sampling, collecting, bioanalysis and draft reports
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In vitro studies which include protein binding using equilibrium dialysis, cell permeability/transporter studies, and microsomal incubations to determine drug metabolism properties
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Method development with LC/MS/MS and extraction techniques for the quantitation of drug in biological fluids
2000-2001:Undergraduate Research Student, Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC
- Developing analytical methods including extraction, cleanup and detection for the existence of aristolochic acids and Aconitum Napellus alkaloids in dietary supplements
1997-2001:Undergraduate Student, George Washington University, Columbian School of Arts and Sciences, Washington, DC
- Bachelor of Science in Chemistry (ACS Certified) with a minor in Marketing
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