Nominations to the Testing Program
Nominations in Review 2006
- Arbutin
- tert-Butylacrylamide
- Ceric Oxide
-
Diazonaphthoquinone derivatives:
- Sodium 1,2-naphthoquinone- 2-diazide-5-sulfonate
- 2,3,4-Trihydroxybenxophenone tris(1,2-naphthoquinonediazide- 5-sulfonate
- 2,3,4-Trihydroxybenzophenone 1,2-naphthoquinonediazide-5- sulfonate
- 3-Dimethylaminopropyl methacrylamide
- Flame Retardants:
- Antimony trioxide
- Decabromodiphenyl oxide
- Tris(chloropropyl)phosphate, mixture of four isomers)
- Phosphonic acid, (3-((hydroxymethyl)amino)-3- oxopropyl)-,dimethyl ester
- Tris(hydroxymethyl)phosphine oxide
- Aromatic Phosphates:
- tert-Butylphenyl diphenyl phosphate
- 2-Ethylhexyl diphenyl phosphate
- Isodecyl diphenyl phosphate
- Phenol, isopropylated, phosphate (3:1)
- Tricresyl phosphate
- Triphenyl phosphate
- Gypsum, natural and synthetic forms
- N-methyl-3-oxobutanamide
Substances for Which No Study is Recommended at this Time:
* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended. Preliminary study recommendations are developed and refined by the nominator, NTP staff, and the ICCEC.
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Arbutin [497-76-7] |
National Institute of Environmental Health Sciences | Consumer exposure through food, cosmetics and dietary supplements; lack of adequate toxicological data; suspicion of toxicity based on chemical structure (1, 6) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
tert-Butylacrylamide [107-48-4] |
National Cancer Institute | High production volume; potential worker and consumer exposures; lack of adequate toxicological data; suspicion of toxicity based on chemical structure (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Ceric oxide [1306-38-3] |
National Institute of Environmental Health Sciences | Widespread industrial use and potential for increasing exposure; demonstrated pulmonary toxicity; lack of toxicity data for nanoscale form (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Diazonaphthoquinone derivatives:
|
National Institute of Environmental Health Sciences | Moderate production volume; potential worker exposures from use in photolithography processes; lack of adequate toxicological data (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
3-Dimethylaminopropyl methacrylamide [5205-93-6] |
National Cancer Institute | High production volume; potential worker and consumer exposures; lack of adequate toxicological data; demonstrated toxicity in short-term studies (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Flame retardants: | Consumer Project Safety Commission | Anticipated increased use in upholstered furniture and bedding and potential consumer exposures from these uses; insufficient toxicity data to assess potential health risks (1, 6, 7) | See individual recommendations |
Antimony trioxide [1309-64-4] |
|
||
Decabromodiphenyl oxide [1163-19-5] |
|
||
Tris(chloropropyl) phosphate, mixture of four isomers [13674-84-5; 76025-08-6; 76649-15-5; 6145-73-9] |
|
||
Phosphonic acid, (3-((hydroxymethyl) amino)-3- oxopropyl)-, dimethyl ester [20120-33-6] |
|
||
Tris(hydroxymethyl) phosphine oxide [1067-12-5] |
|
||
Aromatic phosphates:
|
For one or more representative aromatic phosphates:
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Gypsum, natural and synthetic forms [13397-24-5] |
Mount Sinai-Irving J. Selikoff Center for Occupational and Environmental Medicine
Operative Plasterers' and Cement Masons' International Association of the United States and Canada |
Widespread worker exposures in numerous occupations and to the general population after destruction of the World Trade Centers in 2001; limited toxicity data to assess potential health risks (1, 2, 3, 6) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
N-methyl-3-oxobutanamide [20306-75-6] |
National Cancer Institute | High production volume; potential worker and environmental exposures; lack of adequate toxicological data (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Phenoxyethyl acrylate [48145-04-6] |
National Cancer Institute | High production volume; potential worker and consumer exposures; lack of adequate toxicological data (1, 6, 7) | Defer pending voluntary data submission through the Extended HPV (EHPV) Program |
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Trifluoromethylbenzene [98-08-8] |
National Cancer Institute | High production volume and potential for increased use; potential worker exposures; lack of adequate toxicological data; demonstrated toxicity in short-term studies (1, 6, 7) |
Defer pending review of:
|
Web page last updated on September 05, 2008