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<title>Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies

U.S. Genome Variation Estimates

CYP2C9 Allele and Genotype Frequencies
 Available polymorphism(s)
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rs number

Common Designations

          Nucleotide change               Amino acid change

Genotyping method

rs1057910

Ex7-75A>C

Ile359Leu

TaqMan

 


 Allele and Genotype Frequencies for Subpopulations

 

BY RACE/ETHNICITY    [top]

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1057910 A C   AA AC CC    
  Non-Hispanic White 93.2 (92.4, 94.0) 6.8 (6.0, 7.6) <0.001 87.1 (85.4, 88.5) 12.3 (10.9, 14.0) 0.6 (0.4, 0.9) <0.001 0.28
  Non-Hispanic Black 98.9 (98.2, 99.4) 1.1 (0.6, 1.8) 97.9 (96.5, 98.7) 2.0 (1.2, 3.4) 0.0 (0.0, 0.3) 0.08
  Mexican American 96.1 (95.1, 96.9) 3.9 (3.1, 4.9) 92.4 (90.4, 93.9) 7.5 (6.0, 9.4) 0.1 (0.0, 0.4) 0.58
  Total* 94.2 (93.6, 94.8) 5.8 (5.2, 6.4)   89.0 (87.9, 90.1) 10.4 (9.4, 11.5) 0.6 (0.4, 0.9)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 

BY AGE*  [top]

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1057910 A C   AA AC CC  
  12-19 94.7 (92.3, 96.4) 5.3 (3.6, 7.7) 0.282 90.1 (86.1, 93.1) 9.1 (6.5, 12.7) 0.7 (0.2, 3.0) 0.326
  20-39 94.9 (93.7, 95.9) 5.1 (4.1, 6.3) 90.6 (88.1, 92.6) 8.6 (6.4, 11.4) 0.8 (0.5, 1.4)
  40-59 93.7 (92.0, 95.1) 6.3 (4.9, 8.0) 87.7 (84.3, 90.5) 12.0 (9.2, 15.5) 0.3 (0.1, 1.0)
  >=60 93.2 (92.1, 94.2) 6.8 (5.8, 7.9) 86.9 (85.0, 88.7) 12.6 (11.0, 14.4) 0.5 (0.1, 1.5)
  Total 94.2 (93.6, 94.8) 5.8 (5.2, 6.4)   89.0 (87.9, 90.1) 10.4 (9.4, 11.5) 0.6 (0.4, 0.9)  

* Includes all participants, regardless of race/ethnicity.

 

BY SEX*  [top]

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1057910 A C   AA AC CC  
  Male 94.5 (93.3, 95.5) 5.5 (4.5, 6.7) 0.390 89.5 (87.3, 91.4) 10.0 (8.3, 12.1) 0.5 (0.2, 0.9) 0.404
  Female 93.9 (93.1, 94.6) 6.1 (5.4, 6.9) 88.6 (87.0, 90.0) 10.7 (9.3, 12.3) 0.7 (0.4, 1.2)
  Total 94.2 (93.6, 94.8) 5.8 (5.2, 6.4)   89.0 (87.9, 90.1) 10.4 (9.4, 11.5) 0.6 (0.4, 0.9)  

* Includes all participants, regardless of race/ethnicity.

 

BY RACE/ETHNICITY AND AGE    [top]

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1057910 A C AA AC CC
  Non-Hispanic White 12-19 93.6 (90.7, 95.7) 6.4 (4.3, 9.3) 87.7 (81.9, 91.7) 12.0 (7.9, 17.7) 0.4 (0.1, 1.6)
  20-39 93.8 (92.0, 95.2) 6.2 (4.8, 8.0) 88.5 (84.8, 91.5) 10.5 (7.6, 14.5) 0.9 (0.6, 1.3)
  40-59 92.8 (90.5, 94.6) 7.2 (5.4, 9.5) 86.0 (81.5, 89.6) 13.6 (10.0, 18.2) 0.4 (0.1, 1.3)
  >=60 92.6 (91.2, 93.7) 7.4 (6.3, 8.8) 85.6 (83.4, 87.6) 13.9 (12.1, 15.8) 0.5 (0.1, 1.9)
  Non-Hispanic Black 12-19 98.6 (97.1, 99.4) 1.4 (0.6, 2.9) 97.2 (94.2, 98.7) 2.8 (1.3, 5.8) 0.0 (NA)
  20-39 98.8 (97.7, 99.4) 1.2 (0.6, 2.3) 97.6 (95.4, 98.8) 2.4 (1.2, 4.6) 0.0 (NA)
  40-59 99.1 (97.8, 99.7) 0.9 (0.3, 2.2) 98.5 (95.9, 99.4) 1.4 (0.5, 4.1) 0.2 (0.0, 1.2)
  >=60 99.3 (98.0, 99.8) 0.7 (0.2, 2.0) 98.6 (96.0, 99.5) 1.4 (0.5, 4.0) 0.0 (NA)
  Mexican American 12-19 96.4 (93.8, 98.0) 3.6 (2.0, 6.2) 93.3 (88.4, 96.2) 6.2 (3.3, 11.3) 0.5 (0.1, 3.7)
  20-39 96.1 (94.9, 97.1) 3.9 (2.9, 5.1) 92.2 (89.8, 94.2) 7.8 (5.8, 10.2) 0.0 (NA)
  40-59 95.4 (93.4, 96.8) 4.6 (3.2, 6.6) 90.9 (86.8, 93.8) 9.0 (6.0, 13.3) 0.1 (0.0, 0.9)
  >=60 97.2 (95.1, 98.4) 2.8 (1.6, 4.9) 94.4 (90.3, 96.9) 5.6 (3.1, 9.7) 0.0 (NA)

 

BY RACE/ETHNICITY AND SEX    [top]

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1057910 A C AA AC CC
  Non-Hispanic White Male 93.8 (92.2, 95.0) 6.2 (5.0, 7.8) 88.0 (85.2, 90.3) 11.6 (9.4, 14.2) 0.4 (0.2, 1.1)
  Female 92.7 (91.8, 93.5) 7.3 (6.5, 8.2) 86.2 (84.3, 87.8) 13.0 (11.2, 15.1) 0.8 (0.5, 1.2)
  Non-Hispanic Black Male 98.7 (97.7, 99.2) 1.3 (0.8, 2.3) 97.3 (95.4, 98.5) 2.7 (1.5, 4.6) 0.0 (NA)
  Female 99.2 (98.6, 99.5) 0.8 (0.5, 1.4) 98.4 (97.3, 99.1) 1.5 (0.9, 2.6) 0.1 (0.0, 0.6)
  Mexican American Male 95.7 (94.1, 96.9) 4.3 (3.1, 5.9) 91.7 (88.8, 93.9) 8.1 (6.1, 10.8) 0.2 (0.1, 0.7)
  Female 96.5 (95.4, 97.4) 3.5 (2.6, 4.6) 93.1 (90.8, 94.8) 6.9 (5.2, 9.2) 0.0 (NA)
Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics