Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies|CCL5

U.S. Genome Variation Estimates

CCL5 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid change

Genotyping method

rs2280788

-95C>G

TaqMan

Allele and Genotype Frequencies for Subpopulations

By Race/Ethnicity
By Age
By Sex
By Race/Ethnicity and Age
By Race/Ethnicity and Sex

BY RACE/ETHNICITY [top]

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs2280788		C	G		CC	CG	GG
	Non-Hispanic White	97.2 (96.8, 97.5)	2.8 (2.5, 3.2)	<0.001	94.6 (93.9, 95.2)	5.2 (4.6, 5.9)	0.2 (0.1, 0.5)	<0.001	0.04
	Non-Hispanic Black	99.3 (98.9, 99.6)	0.7 (0.4, 1.1)		98.7 (97.8, 99.2)	1.3 (0.8, 2.2)	0.0 (NA)		0.79
	Mexican American	98.7 (98.3, 99.0)	1.3 (1.0, 1.7)		97.4 (96.6, 98.0)	2.6 (2.0, 3.4)	0.0 (NA)		0.63
	Total*	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

BY AGE^* [top]

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2280788		C	G		CC	CG	GG
	12-19	98.0 (95.5, 99.1)	2.0 (0.9, 4.5)	0.250	96.0 (91.2, 98.2)	4.0 (1.8, 8.8)	0.0 (NA)	0.019
	20-39	96.8 (96.1, 97.4)	3.2 (2.6, 3.9)		93.7 (92.4, 94.8)	6.2 (5.2, 7.4)	0.1 (0.0, 0.6)
	40-59	97.6 (96.7, 98.2)	2.4 (1.8, 3.3)		95.3 (93.4, 96.6)	4.6 (3.2, 6.6)	0.1 (0.0, 0.8)
	>=60	97.9 (97.1, 98.5)	2.1 (1.5, 2.9)		96.0 (94.5, 97.0)	3.8 (2.9, 5.1)	0.2 (0.1, 0.7)
	Total	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

BY SEX^* [top]

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2280788		C	G		CC	CG	GG
	Male	97.8 (97.1, 98.3)	2.2 (1.7, 2.9)	0.172	95.6 (94.4, 96.6)	4.4 (3.4, 5.6)	0.1 (0.0, 0.5)	0.452
	Female	97.0 (96.1, 97.7)	3.0 (2.3, 3.9)	0.172	94.2 (92.6, 95.5)	5.6 (4.4, 7.1)	0.2 (0.1, 0.6)	0.452
	Total	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

BY RACE/ETHNICITY AND AGE [top]

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs2280788			C	G	CC	CG	GG
	Non-Hispanic White	12-19	97.9 (95.2, 99.1)	2.1 (0.9, 4.8)	95.9 (90.4, 98.3)	4.1 (1.7, 9.6)	0.0 (NA)
		20-39	96.4 (95.5, 97.2)	3.6 (2.8, 4.5)	93.1 (91.4, 94.4)	6.7 (5.4, 8.3)	0.2 (0.0, 0.8)
		40-59	97.5 (96.5, 98.2)	2.5 (1.8, 3.5)	95.1 (93.0, 96.6)	4.7 (3.2, 7.0)	0.2 (0.0, 1.0)
		>=60	97.7 (96.8, 98.4)	2.3 (1.6, 3.2)	95.7 (94.1, 96.9)	4.0 (3.0, 5.4)	0.2 (0.1, 0.9)
	Non-Hispanic Black	12-19	99.5 (98.6, 99.8)	0.5 (0.2, 1.4)	98.9 (97.2, 99.6)	1.1 (0.4, 2.8)	0.0 (NA)
		20-39	99.2 (98.4, 99.6)	0.8 (0.4, 1.6)	98.5 (96.8, 99.3)	1.5 (0.7, 3.2)	0.0 (NA)
		40-59	99.2 (98.1, 99.7)	0.8 (0.3, 1.9)	98.5 (96.1, 99.4)	1.5 (0.6, 3.9)	0.0 (NA)
		>=60	99.7 (98.7, 99.9)	0.3 (0.1, 1.3)	99.4 (97.4, 99.9)	0.6 (0.1, 2.6)	0.0 (NA)
	Mexican American	12-19	98.2 (96.2, 99.1)	1.8 (0.9, 3.8)	96.3 (92.5, 98.2)	3.7 (1.8, 7.5)	0.0 (NA)
		20-39	98.9 (98.2, 99.4)	1.1 (0.6, 1.8)	97.8 (96.4, 98.7)	2.2 (1.3, 3.6)	0.0 (NA)
		40-59	98.7 (98.0, 99.1)	1.3 (0.9, 2.0)	97.3 (95.9, 98.2)	2.7 (1.8, 4.1)	0.0 (NA)
		>=60	98.9 (97.5, 99.5)	1.1 (0.5, 2.5)	97.7 (95.1, 99.0)	2.3 (1.0, 4.9)	0.0 (NA)

BY RACE/ETHNICITY AND SEX [top]

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs2280788			C	G	CC	CG	GG
	Non-Hispanic White	Male	97.4 (96.5, 98.0)	2.6 (2.0, 3.5)	94.9 (93.2, 96.2)	5.0 (3.8, 6.7)	0.1 (0.0, 0.7)
		Female	97.0 (96.3, 97.6)	3.0 (2.4, 3.7)	94.3 (93.0, 95.4)	5.4 (4.4, 6.7)	0.3 (0.1, 0.9)
	Non-Hispanic Black	Male	99.3 (98.6, 99.7)	0.7 (0.3, 1.4)	98.6 (97.1, 99.4)	1.4 (0.6, 2.9)	0.0 (NA)
		Female	99.4 (98.8, 99.7)	0.6 (0.3, 1.2)	98.7 (97.6, 99.4)	1.3 (0.6, 2.4)	0.0 (NA)
	Mexican American	Male	98.9 (97.8, 99.4)	1.1 (0.6, 2.2)	97.7 (95.6, 98.8)	2.3 (1.2, 4.4)	0.0 (NA)
		Female	98.5 (97.6, 99.1)	1.5 (0.9, 2.4)	97.1 (95.1, 98.3)	2.9 (1.7, 4.9)	0.0 (NA)

Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics