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NCI Materials
Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Selenium and Vitamin E Supplements
(Posted: 10/27/2008) - Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E and a small, but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium.
Selenium and Vitamin E Cancer Prevention Trial (SELECT)
(Posted: 10/31/2008, Updated: 12/09/2008) - SELECT is continuing to evaluate the effects of the supplements, but participants are no longer taking study supplements. The independent Data and Safety Monitoring Committee for the trial found that selenium and vitamin E, taken alone or together for an average of five and one-half years, did not prevent prostate cancer.
Largest-Ever Prostate Cancer Prevention Trial Opens: 32,000 Men Sought to Test Vitamin E and Selenium
(Posted: 07/24/2001) - Healthy men age 55 and older are needed for the largest-ever prostate cancer prevention study, launched today by the NCI and a network of researchers known as the Southwest Oncology Group (SWOG). Questions and Answers
Phase III Randomized Study of Selenium and Vitamin E for the Prevention of Prostate Cancer (SELECT Trial)
A summary of the SELECT protocol statement.
SELECT Data: Enrollment Statistics
(Updated: 09/04/2003) - Enrollment data from SELECT, the Selenium and Vitamin E Cancer Prevention Trial.
La revisión del estudio de prevención de cáncer de próstata indica no haber beneficio del uso de suplementos de selenio y de vitamina E
(Publicación: 10/27/2008, Actualización: 12/09/2008) - La revisión inicial, independiente, de los datos del estudio SELECT, sigla en inglés del Estudio del Selenio y la Vitamina E para Prevenir el Cáncer, financiado por el Instituto Nacional del Cáncer (NCI) y otros institutos que comprenden los Institutos Nacionales de la Salud (NIH), indica que los suplementos de selenio y de vitamina E, tomados juntos o por separado, no impiden el cáncer de próstata. Los datos indicaron también dos tendencias preocupantes: un pequeño aumento aunque no significativo estadísticamente en el número de casos de cáncer de próstata entre los más de 35 000 hombres de 50 años y mayores en el estudio que tomaron sólo vitamina E, y un aumento pequeño aunque no significativo estadísticamente en el número de casos de diabetes de aparición en edad adulta en los hombres que tomaron sólo el selenio.
Se inagura estudio de prevención de cáncer de próstata
(Publicación: 07/24/2001) - Más de 400 centros en los Estados Unidos, Puerto Rico y Canadá están aceptando participantes para SELECT. Este estudio durará 12 años. SELECT es el primer estudio diseñado para observar directamente los efectos del selenio y la vitamina E, tanto juntos como por separado, para prevenir el cáncer de próstata.
Prostate Cancer Prevention Trial (PCPT): Questions and Answers
(Posted: 06/24/2003, Updated: 05/18/2008) - In the Prostate Cancer Prevention Trial (PCPT), 25 percent fewer men taking the drug finasteride developed prostate cancer than men not taking the drug. However, men who developed prostate cancer while taking finasteride were more likely to have high-grade cancers, which can spread quickly even if the tumors are small.
HOPE-TOO: NCI Comment on Published Results
(Posted: 03/15/2005) - A report published in the March 16 issue of the Journal of the American Medical Association finds no clear evidence that men and women who had vascular disease or diabetes and who took 400 i.u. of vitamin E daily for 7 years reduced their risk of cancer compared to others with these conditions who took a placebo.
Prostate Cancer Prevention (PDQ®)
[ patient ] [ health professional ]
Expert-reviewed information summary about factors that may influence the risk of developing prostate cancer and about research aimed at the prevention of this disease.
Best Leads for Prostate Cancer Prevention Appear in April Urology Supplement; Agents, Biomarker Endpoints, Cohorts, and Trial Designs Outlined
(Posted: 04/09/2001) - The most promising agents to prevent prostate cancer and the most likely biological markers of risk for the disease are just two of the key areas of prostate cancer prevention research highlighted.
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