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Optimization of Small Molecule Probes for the Nervous System (R21)
Release Date: December 30, 2008
Announcement Number: RFA-NS-09-003
Application Receipt Date:
March 3, 2009
Letter of Intent Date: February 3, 2009
Funding Contact: Mark Scheideler, Ph.D.
Program Area: Office of Translational Research
Brief Description:
The aim of this FOA issued by the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute
on Alcohol Abuse and Alcoholism (NIAAA), and the National Institute on Drug Abuse (NIDA) is to facilitate the discovery of
new small molecule probes for investigating biological function in the nervous system by providing funding for advanced medicinal
chemistry and the biological testing of compounds. Eligible Investigators will have identified probe candidates via screening
of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and
be able to show that the structural features of these small molecules are related to their biological activity. Project proposals
should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing
of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium
throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing
the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the
investigator. Applicants are strongly encouraged to utilize publicly available cheminformatic capabilities for the acquisition
of compounds, and semi-custom synthesis of analogues, which is required of these studies.
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