National Toxicology Program

Draft Reports, Public Comments & Meeting Presentations

• Overview of genetically modified models (Dr. John French, NIEHS)
  
  
• GMM-07: Toxicology Studies of Allyl Bromide (CAS No. 106-95-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6.129-Trp53^tm1Brd (N5) Haploinsufficient] Mice (Gavage Studies)
  (abstract) (full draft report)
• Public Comments: none received
  
• Meeting Presentation
  

• GMM-08: Toxicology and Carcinogenesis Study of Benzene (CAS No. 71-43-2) in Genetically Modified Haploinsufficient p16^Inka4a/p19^Arf Mice (Gavage Study)
  (abstract) (full draft report)
  
• Public Comments: none received
• Meeting Presentation
  

• GMM-09:  Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F₁ Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53^tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies)
  (abstract) (full draft report)
  
• Public Comments: none received
• Meeting Presentation
  

• GMM-12: Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient p16^Ink4a/p19^Arf Mice (Feed Study)
  (abstract) (full draft report)
  
• Public Comments: none received
• Meeting Presentation
  

• GMM-13: Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient p16^Ink4a/p19^Arf Mice (Gavage Study)
  (abstract) (full draft report)
  
• Public Comments: will be added as received
• Meeting Presentation
  
  
• Utility of genetically modified models for cancer hazard identification (Dr. John Bucher, NIEHS)