Advisory Board & Committees
BSC Technical Reports Review Subcommittee: Summary Data and Levels of Evidence December 11-12, 1996
CHEMICAL CAS NUMBER |
TECHNICAL REPORT NUMBER |
PRIMARY USES | ROUTE/ EXPOSURE LEVELS |
REVIEW ACTIONS |
---|---|---|---|---|
3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) 30516-87-1 and
INTERFERON AD + AZT
| TR-469 | Pyrimidine nucleoside analog with antiviral activity used in the treatment of AIDS (Merck
1989).
| (Gavage 5% Methylcellulose): Mice only: 0, 30, 60, OR 120 MG/KG; 50/SEX Subcutaneous Inj. + Gavage (.5% Methylcellulose): Dual routes with both compounds: AZT: 0, 30, 60, or 120 (gav) mg/kg; IFN: 500 OR 5000 units 3x/week | The Subcommittee accepted the conclusions as written, equivocal evidence of carcinogenic activity, for male B6C3F1 mice receiving AZT alone,and, clear evidence of carcinogenic activity, for female mice receiving AZT alone or in combination -interferon. |
CHLOROPRENE 126-99-8 | TR-467 | Monomer for neoprene elastomers; industrial rubber products; component of laboratory adhesives in food packaging. | Inhalation (Air): Rats & Mice: 0, 12.8, 32.0, OR 80.0 PPM; 50/SEX/ SPECIES/GROUP | The Subcommittee accepted the conclusions as written, clear evidence of carcinogenic activity, for male and female F344 rats and male and female mice. |
COBALT SULFATE HEPTAHYDRATE 10026-24-1 | TR-471 | Drying agent for varnishes and inks; component of electroplating solutions | Inhalation (Air): Rats & Mice: 0, 0.3, 1.0, OR 3.0 MG/M3; 50/SEX/SPECIES/GROUP | The Subcommittee accepted the conclusions as written, some evidence of carcinogenic activity, for male rats, and, clear evidence of carcinogenic activity, for female rats and male and female mice. |
ETHYLBENZENE 100-41-4 | TR-466 | Manufacture of synthetic rubber. Solvent. Fuel additive. Chemical intermediate. | Inhalation (Air) Rats & Mice: 0, 75, 250, 750 PPM (50/SEX/SPECIES/GROUP) | The Subcommittee accepted the conclusions as written, clear evidence of carcinogenic activity, for male rats, and, some evidence of carcinogenic activity, for female rats and male and female mice. |
ISOBUTYRALDEHYDE 78-84-2 | TR-472 | Synthesis of pantothenic acid, cellulose esters, perfumes, flavors, and gasoline additives. Chemical intermediate. | Inhalation (Air): Rats & Mice: 0, 500, 1000, OR 2000 PPM (50/SEX/ SPECIES/GROUP) | The Subcommittee accepted the conclusions as written, no evidence of carcinogenic activity, for male and female rats and male and female mice. |
OXAZEPAM 604-75-1 | TR-468 | Tranquilizer | Dosed-Feed (NIH-07): Rats only: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP | The Subcommittee recommended that the conclusion in male rats be changed from some evidence of carcinogenic activity to equivocal evidence of carcinogenic activity, while accepting the conclusion as written, no evidence of carcinogenic activity, for female rats. |
POLYVINYL ALCOHOL 9002-89-5 | TR-474 | PVA film for intravaginal administration of spermicides. Textile warp sizing and inishing. adhesives. Pesticides. Pigment in TV picture tubes. | Intravaginal (Deionized Water): Mice only: 25% PVA, VEHICLE, UNTREATED; 100/GROUP | The Subcommittee accepted the conclusion as written, no evidence of carcinogenic activity, for female mice. |
PRIMIDONE (PRIMACLONE) 125-33-7 | TR-476 | Prophylactic management of partial grand mal and psychomotor seizures that are refractory to other antiepileptic drugs. | Dosed-Feed (NIH-07 Mice: 0, 0.03, 0.06, OR 0.13% Rats: 0, 0.06, 0.13, OR 0.25% (50/SEX/SPECIES) | The Subcommittee accepted the conclusions as written, equivocal evidence of carcinogenic activity, for male rats, no evidence of carcinogenic activity, for female rats, and , clear evidence of carcinogenic activity, for male and female mice. |
TETRAHYDROFURAN 109-99-9 | TR-475 | Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. | Inhalation (Air): Rats & Mice: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP) | The Subcommittee accepted the conclusions as written, some evidence of carcinogenic activity, for male rats, no evidence of carcinogenic activity, for female rats and male mice, and, clear evidence of carcinogenic activity, for female mice. |
THEOPHYLLINE 58-55-9 | TR-473 | Diuretic, cardiac stimulant, smooth muscle relaxant, antiasthmatic, occurs naturally in tea (Merck 1989) | Gavage (Corn Oil): Rats: 0, 7.5, 25, OR 75 MG/KG; 50/GROUP Female Mice: 0, 7.5, 25, OR 75 MG/KG; 50/GROUP Male Mice: 0, 15, 50, OR 150 MG/KG; 50/GROUP | The Subcommittee accepted the conclusions as written, no evidence of carcinogenic activity, for male and female rats and male and female mice. |
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