Structure And Function Of The Nicotinic Receptor: Insights From Mutagenesis, Structural Modeling And Single Channel Recording |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Monday, May 06, 2002, 12:00:00 PM |
| Category: | Neuroscience |
| Description: | The NIH Neuroscience Lecture Series features lectures and discussions with leading neuroscientists.
Dr. Sine studies nicotinic receptors at the neuromuscular junction and in the brain. His work is focussed on understanding how agonist binding is transduced into opening of the ion channel intrinsic. In collaboration with Andy Engle he has studied the molecular mechanisms of congenital myasthenic syndromes, diseases that produce profound muscle weakness. Their work has shown that many of these syndromes result from mutations in nicotinic receptors. Analysis of changes in Ach receptor function produced by these mutations is giving profound insight into the gating mechanism, revealing novel sites of regulation that in all probability would not have been discovered were it not for the fact they were identified in myasthenic patients. For more information, visit the NIH Neuroscience Seminar Series |
| Author: | Steven Sine, PH.D., Mayo Foundation |
| Runtime: | 75 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 10892 |
| CIT Live ID: | 1045 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10892 |