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Alternate Title Randomized Study of Surveillance For the Early Detection of Lung Cancer in Current or Former Smokers With Mild to Moderate Chronic Obstructive Pulmonary Disease
Trial Description Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat. This randomized clinical trial is studying screening tests or exams to see how well they work compared to usual care in finding early stage lung cancer in current or past smokers with chronic obstructive pulmonary disease. Eligibility criteria include the following:
Final eligibility for a clinical trial is determined by the health professionals conducting the trial. Patients will be randomly assigned (have an equal chance of being placed) to one of two groups. Patients in group one will be evaluated for 5 years. After 5 years, some patients may undergo a chest x-ray. Patients in group two will undergo screening for lung cancer for 5 years. Blood samples will be collected once a year. Sputum samples will also be collected. Patients with a normal sputum sample will undergo sputum sample collection once a year. Patients with an abnormal sputum sample will undergo a spiral CT scan once a year and bronchoscopy every 4-12 months. If invasive cancer is found, the patient will be referred to their personal doctor for treatment. Any remaining sputum samples will be stored for future laboratory studies. Important: For more details about this trial, refer to the Health Professional version of the trial summary. If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site. Trial Lead Organizations Cancer Research UK and University College London Cancer Trials Centre
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