Biomarkers in Screening Participants For Lung Cancer
Last Modified: 11/12/2007  First Published: 2/21/2006
Alternate Title Basic Trial Information Trial Description Purpose Eligibility Treatment/Intervention Trial Contact Information Registry Information
Alternate Title
Screening Study of Biomarkers Associated With the Early Detection of Lung Cancer in Participants at High- or Low-Risk For Smoking-Related Cancer
Basic Trial Information
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Phase
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Type
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Status
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Age
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Sponsor
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Protocol IDs
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No phase specified
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Biomarker/Laboratory analysis, Screening
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Active
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Over 50
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NCI
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NYU-H-8896-06-B NCT00301119
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Trial Description Purpose: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer.
This clinical trial is studying biomarkers in screening participants for lung cancer. Eligibility: Eligibility criteria include the following: Final eligibility for a clinical trial is determined by the health professionals conducting the trial. Treatment/Intervention: Participants will complete a questionnaire and undergo a breathing test, a chest CT scan, and have sputum and blood samples collected. Some participants may undergo bronchoscopy and biopsy, or surgery. Tissue samples will be collected during surgery or biopsy.
Important: For more details about this trial, refer to the Health Professional version 6 of the trial summary. If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on
NCI's Web site 7.
Trial Contact Information
Trial Lead Organizations NYU Cancer Institute at New York University Medical Center ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | William Rom, MD, MPH, Principal investigator | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Trial Sites
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U.S.A. |
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New York |
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New York |
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| | | | | | | | NYU Cancer Institute at New York University Medical Center |
| | William Rom, MD, MPH | |
| Email:
william.rom@med.nyu.edu |
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Registry Information | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Official Title | | NYU Lung Cancer Biomarker Center | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Trial Start Date | | 2000-05-08 | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Trial Completion Date | | 2010-02-28 (estimated) | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Registered in ClinicalTrials.gov | | NCT00301119 8 | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Date Submitted to PDQ | | 2005-10-04 | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | Information Last Verified | | 2008-12-07 | ![](https://webarchive.library.unt.edu/eot2008/20090116171825im_/http://www.cancer.gov/images/spacer.gif) | NCI Grant/Contract Number | | U01-CA86137, P30-CA16087 |
Glossary Terms
biomarker (BY-oh-MAR-ker)
A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
biopsy (BY-op-see)
The removal of cells or tissues for examination by a pathologist. The pathologist may study the tissue under a microscope or perform other tests on the cells or tissue. There are many different types of biopsy procedures. The most common types include: (1) incisional biopsy, in which only a sample of tissue is removed; (2) excisional biopsy, in which an entire lump or suspicious area is removed; and (3) needle biopsy, in which a sample of tissue or fluid is removed with a needle. When a wide needle is used, the procedure is called a core biopsy. When a thin needle is used, the procedure is called a fine-needle aspiration biopsy.
blood
A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
bronchoscopy (bron-KOS-koh-pee)
A procedure that uses a bronchoscope to examine the inside of the trachea, bronchi (air passages that lead to the lungs), and lungs. A bronchoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue to be checked under a microscope for signs of disease. The bronchoscope is inserted through the nose or mouth. Bronchoscopy may be used to detect cancer or to perform some treatment procedures.
cell (sel)
The individual unit that makes up the tissues of the body. All living things are made up of one or more cells.
clinical trial
A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Also called clinical study.
CT scan
A series of detailed pictures of areas inside the body taken from different angles. The pictures are created by a computer linked to an x-ray machine. Also called CAT scan, computed tomography scan, computerized axial tomography scan, and computerized tomography.
eligibility criteria
In clinical trials, requirements that must be met for an individual to be included in a study. These requirements help make sure that patients in a trial are similar to each other in terms of specific factors such as age, type and stage of cancer, general health, and previous treatment. When all participants meet the same eligibility criteria, it gives researchers greater confidence that results of the study are caused by the intervention being tested and not by other factors.
lung cancer (lung KAN-ser)
Cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope.
screening (SKREEN-ing)
Checking for disease when there are no symptoms. Since screening may find diseases at an early stage, there may be a better chance of curing the disease. Examples of cancer screening tests are the mammogram (breast), colonoscopy (colon), Pap smear (cervix), and PSA blood level and digital rectal exam (prostate). Screening can also include checking for a person’s risk of developing an inherited disease by doing a genetic test.
sputum (SPYOO-tum)
Mucus and other matter brought up from the lungs by coughing.
surgery (SER-juh-ree)
A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.
tissue (TISH-oo)
A group or layer of cells that work together to perform a specific function.
tumor (TOO-mer)
An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancerous), or malignant (cancerous). Also called neoplasm.
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Table of Links
1 | http://www.cancer.gov/clinicaltrials/learning |
2 | http://www.cancer.gov/cancertopics/factsheet/Information/clinical-trials |
3 | http://www.cancer.gov/clinicaltrials/learning/questions-to-ask-about-participat ing |
4 | http://www.nlm.nih.gov/medlineplus/druginformation.html |
5 | http://www.cancer.gov/clinicaltrials/NYU-H-8896-06-B#EntryCriteria_CDR0000456198 |
6 | http://www.cancer.gov/clinicaltrials/NYU-H-8896-06-B |
7 | http://cancer.gov/clinicaltrials |
8 | http://clinicaltrials.gov/ct/show/NCT00301119 |
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