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McKesson
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The indicator monitors temperature exposure, not product quality 

Vaccine Temperature Management
A ColdMark™ Freeze Indicator has been packaged with this shipment by
McKesson to assure that the enclosed vaccines have been shipped under manufacturer-recommended conditions.

Receiver Instructions
Immediately upon shipment receipt:
• Remove the ColdMark Freeze Indicator from the shipment container
• Store vaccines as instructed below
• Follow instructions on reverse side to utilize the ColdMark Freeze
Indicator properly

Vaccine Storage Requirements
• Take the product out of the shipment container immediately upon
shipment receipt
• If damage is evident, contact your Project Point of Contact (PPOC)
within 2 hours of shipment receipt
• Remove the product from the zippered plastic bag
• Refrigerate immediately
• Store at 35° to 46°F (2° to 8°C)
• Do not freeze or expose to freezing temperatures
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McKesson
Empowering Healthcare

How to Read
Immediately upon shipment receipt, remove the ColdMark Freeze Indicator and check the ColdMark bulb.
• If the bulb is clear and colorless, begin using vaccine as needed.
• If the bulb appears violet in color, store the product as instructed and contact your PPOC for further instructions prior to using.

ColdMark Freeze Indicator decision table:

Bulb Color: Vaccine Type:  MMR, ActHIB, LAIV
Clear and Colorless:  Begin using vaccine
Violet:  Begin using vaccine

Bulb Color:  Vaccine type:  All other vaccine
Clear and Colorless: Begin using vaccine 
Violet: Contact PPOC
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This document can be found on the CDC website at:
http://www.cdc.gov/vaccines/programs/vmbip/downloads/newsletters/ipc-coldmark.rtf