Frederick W. Miller, M.D., Ph.D.
Tel (301) 451-6273
Fax (301) 451-5585
NIH 10, Room 4-2352
10 Center Drive, MSC 1301
Bethesda, Maryland 20892-1301
The mission of the Environmental Autoimmunity Group (EAG) is to understand the mechanisms for the development of autoimmune diseases so that group members can extend healthy life and reduce the burdens of illness and disability. The group conducts a broad program of clinical and basic investigation in the area of adult and pediatric autoimmune diseases. The EAG uses multidisciplinary approaches to understand the roles of genetic and environmental risk factors for these diseases. Group members are currently focusing investigations on the Systemic Rheumatic Diseases. These diseases include Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis (Scleroderma) and the Idiopathic Inflammatory Myopathies (DermatoMyositis, Polymyositis, Inclusion Body Myositis and related Myositis Syndromes). These diseases are heterogeneous groups of disorders defined by chronic inflammation, as prototypic autoimmune diseases. EAG studies include epidemiologic surveys, molecular genetic studies and clinical investigations in disease pathogenesis, as well as the development of clinical tools for assessment of innovative therapies.
The EAG supports studies at the NIH Clinical Center (http://www.niehs.nih.gov/research/clinical/join/bethesda/index.cfm).
Major areas of research: