NIAID HIV/OI Searchable Chemical Database

HIV Life Cycle

1. Attachment
   • CD4-gp120 Interaction
   • Gp120-Chemokine Receptor Interaction
2. Viral Fusion/Uncoating
3. Reverse Transcription
4. RNaseH Degradation
5. Second Strand Synthesis
6. Migration to Nucleus
7. Integration
8. Latency
9. Early Transcription
10. Late Transcription
11. RNA Processing
12. Protein Synthesis
13. Protein Glycosylation
14. Assembly of Virion
15. Viral Budding
16. Virion Maturation
17. Other

Modified from M. Nasr, J. Cradock and M. Johnston, Drug News and Perspectives Vol. 6 pg 338; Courtesy of J.R. Prous S.A. Barcelona, Spain