|
February 2005
HIV Vaccines Questions and Answers for
HIV Prevention Workers
- Why do I need to know about HIV vaccine research?
As a prevention worker, you are in contact with different segments
of the community and many people will turn to you for all types of
information about HIV. Therefore, it is important for you to be able
to answer questions concerning HIV vaccines, microbicides and other
areas of HIV prevention research, in addition to providing information
about HIV testing and risk reduction. Also, some of the people you
are in contact with may be enrolled in an HIV vaccine trial and it
is important for you to know how it can affect them and their seropositive
status.
- How does HIV vaccine research affect HIV prevention activities?
An HIV vaccine that is simple to administer, inexpensive, and effective,
would be the most optimal prevention strategy. However, even when
an HIV vaccine becomes widely available, a combination of preventive
approaches will likely be required to protect individuals and the
public against HIV infection, and control the global AIDS epidemic.
Such approaches include: -
- Prevention strategies directed at individuals or communities for
reducing risk of HIV transmission associated with sexual activity
and/or with injection drug use
- Microbicides for vaginal or rectal use
- Antiretroviral therapy to care for those already infected and
to reduce the infectiousness of HIV-infected persons
- Treatment of sexually transmitted infections (STIs) that are cofactors
for HIV transmission
- Prophylaxis to prevent mother-to-child transmission
- A safe and effective HIV vaccine
In this context, HIV vaccines can be viewed as an integral component
of a comprehensive HIV prevention strategy.
- What are the basic facts about HIV vaccines?
There are several important things you need to know about HIV vaccines.
- HIV vaccines being tested in humans do not contain HIV and
cannot cause HIV.
- If HIV vaccine trial participants engage in behaviors that
expose them to HIV, they may become infected with HIV. In your
capacity as a prevention worker, it is important for you to continue
to stress the importance of comprehensive risk-reduction strategies
that will reduce the risk of HIV infection, just as you would with
others in the community.
- At present, there is not an HIV vaccine. Contrary to
what some people in the community may think, an HIV vaccine is not
currently available. Research is underway to find a safe and effective
vaccine that will protect people from being infected with HIV, but
it will continue to take more time until a promising vaccine is
discovered.
- How does an HIV vaccine affect someone's seropositive status?
Some HIV vaccines stimulate the production of antibodies against
multiple HIV proteins. Since standard HIV tests (e.g., ELISA) detect
antibodies in blood directed against certain HIV proteins, a person
who is receiving an HIV vaccine could test positive for HIV. The HIV
vaccines being tested do not contain HIV and, therefore, cannot cause
HIV infection. Other tests are available to determine if an HIV vaccine
trial volunteer is actually infected with HIV as a result of his or
her own behavior-related to exposure to HIV.
- How will I know if someone is an HIV vaccine trial participant?
Prior to testing, it would be a good idea for you to ask if the individual
is participating or has participated in an HIV vaccine trial. If the
answer is yes, you should refer them back to their research site for
HIV counseling and testing. Staff at the site will be able to provide
testing that can differentiate between a volunteer actually being
infected as a result of his or her own behavior and a positive result
induced by the vaccine. If the volunteer knows they received placebo,
or otherwise does not have circulating antibodies from the vaccine
and their follow-up in the trial has been terminated, testing can
proceed as usual.
- Should I refuse to provide HIV testing to an HIV vaccine trial
participant?
If an HIV vaccine trial volunteer wants to be tested at your site
rather than return to his/her research site for testing, you should
make note that this individual is participating in an HIV vaccine
study on the laboratory form. You should also request that, if the
ELISA and Western Blot tests are positive, that a PCR (Polymerase
Chain Reaction) test be conducted in order to determine whether the
volunteer is actually infected with HIV as a result of his or her
own behavior-related exposure to HIV.
- What if an HIV vaccine trial volunteer still wants to be tested
at my clinic/health center?
If an HIV vaccine trial volunteer wants to be tested at your site
rather than return to his/her research site for testing, you should
make note that this individual is participating in an HIV vaccine
study on the laboratory form. You should also request that, if the
ELISA and Western Blot tests are positive, that a PCR (Polymerase
Chain Reaction) test be conducted in order to determine whether the
volunteer is actually infected with HIV as a result of his or her
own behavior-related exposure to HIV.
- Where can I go for more information?
For more detailed information about HIV vaccine and current research,
you can visit the National Institute of Allergy and Infectious Diseases
(NIAID) website at http://www.niaid.nih.gov/daids/vaccine/default.htm,
the HIV Vaccine Trials Network at http://www.hvtn.org
or the Vaccine Research Center at www.niaid.nih.gov/vrc.
For general information about HIV vaccines as well as a comprehensive
database that can be searched for HIV vaccine trials by location or
product, you can visit the AIDSinfo website at http://aidsinfo.nih.gov/.
Publications
Home | Search
Last Updated February 23, 2005 (ere)
|