Summaries & Associations of Study Results
TR-382 Furfural
Target Organs and Levels of Evidence
NTP Technical Report Number 382
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| FURFURAL 98-01-1 |
11/20/89 | INTERMED. IN PLASTICS PREPARATION, WETTING & FLAVORING AGENT, PREP'N OF FURFURAL ALCOHOL, INSECTICIDE, FUNGICIDE, GERMICIDE, REFINING PETROLEUM OILS, SOLVENT FOR COTTON, DYES (HSDB 1990). OCCURS IN ESSENTIAL OILS, COFFEE, RUM (FOOD, COSM TOX) | Gavage R: 0,30,60, M: 0,50,100,175 MG/KG/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | LIVER: CHOLANGIOCARCINOMA 0/50 0/50 2/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: BILE DUCT, DYSPLASIA AND FIBROSIS | |||
| FR: NO EVIDENCE | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50 | |||
| MAY HAVE BEEN RELATED: | KIDNEY TUBULAR CELL: ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50 | |||
| FM: SOME EVIDENCE | LIVER: ADENOMA 1/50 3/50 5/50 8/50 | |||
| MAY HAVE BEEN RELATED: | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50 | |||
Web page last updated on February 10, 2006
