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| Christian Grillon, Ph.D., Investigator |
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Dr. Grillon received his master degree from the University of Paris VI, France, and his Ph.D. from the University of Paris XI, where he studied motor responses in depressed individuals in the laboratory of Dr. A. Hugelin. During a postdoctoral fellowship with David Braff at the University of California, San Diego, he investigated sensorimotor gating mechanisms using the prepulse inhibition of the startle reflex paradigm in schizophrenics. Dr. Grillon jointed the faculty in the Psychiatry Department at Yale University Medical School in 1988 and moved to NIMH as an Investigator in 2001. His laboratory is studying the neurobiology of anxiety and anxiety disorders, and the psychophysiology of emotion.
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Staff:
Clinical Protocols:
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Effects of arousal and stress on classical conditioning ( 01-M-0185 )
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Effect of D-cycloserine on extinction of fear conditioning in humans ( 02-M-0157 )
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Effect of Alprazolam on Fear-Potentiated Startle in Humans ( 02-M-0263 )
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Fear conditioning using computer-generated virtual reality ( 02-M-0003 )
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fMRI investigation of explicit cue and contextual fear ( 02-M-0321 )
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Predictability and Aversive Expectancies in Anxiety Disorders ( 03-M-0093 )
Selected Recent Publications:
Grillon,C., Cordova,J., Levine, L., Morgan, C.A., III (InPress) Anxiolytic effects of the group II metabotropic glutamate receptors LY354740 in the fear-potentiated sartle paradigm in humans, Psychopharmacology.
Grillon, C. (2002) Associative learning deficits increase symptoms of anxiety in humans, Biological Psychiatry 51, 851-858.
Grillon C (2002) Startle reactivity and anxiety disorders: Aversive conditioning, context, and neurobiology, Biological Psychiatry 52, 958-975.
Contact Information:
Dr. Christian Grillon
Neurophysiology and Behavior Unit
Mood and Anxiety Disorders Program, NIMH
Building 10, Room 3N212
10 Center Drive MSC 1279
Bethesda, MD 20892-1279
Telephone: (301) 594-2894 (office),
(301) 594-9959 (fax)
Email: grillonc@intra.nimh.nih.gov
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