Headaches can be a direct result of the interferon. They can also be due to anemia (low red blood cells) caused by ribavirin.
Quick Tips: Headaches
Drink more fluids.
Try to get plenty of sleep.
Take a hot, relaxing bath.
Lie down and rest in a quiet, dark room.
Try to reduce your stress level.
Check with your VA health care provider about taking Tylenol and/or ibuprofen.
If you have a history of migraine headaches (a certain type of headache, which often comes with vision changes), talk to your health care provider about taking medications (such as Imitrex) for them.