About the Brain Tumor Progress Review Group
The National Cancer Institute (NCI) supports basic, clinical, and population-based research to identify and study the causes,
biology, prevention, early detection, and treatment of cancer, while the National Institute of Neurological Disorders and
Stroke (NINDS) is the Nation's leading supporter of biomedical research on disorders of the brain and nervous system. Through
years of dedicated research, researchers supported by both Institutes have amassed a significant knowledge base about brain
tumors, and this knowledge, coupled with new technologies, is providing a wealth of new scientific opportunities. At the same
time, increasing research needs and scientific opportunities require that the Institutes determine the best uses for their
resources. It is necessary to identify clear scientific priorities, both to provide guidance for the scientific community
and to create a benchmark against which progress can be measured.
Progress Review Groups (PRGs) were originally established to assist the NCI in assessing the state of knowledge and identifying
scientific opportunities and needs within its large, site-specific research programs. PRGs fit within the NCI's overall planning
framework, which embraces the use of expert panels and includes the establishment of Working Groups, which are specifically
focused on aspects of scientific discovery and technology, as well as more broadly focused Program Review Groups. The Brain
Tumor Progress Review Group (BT-PRG) was the first PRG to be jointly established between NCI and NINDS, in recognition of
the importance of brain tumor research to both Institutes.
CHARGE TO THE PRG
The BT-PRG was charged with assisting NCI and NINDS in addressing the two Institutes' brain tumor research programs. PRG members
were asked to take a broad view in identifying and prioritizing unmet scientific needs and opportunities that are critical
to the advancement of the research field. The BT-PRG was specifically charged with the following:
This report is the final product of the Brain Tumor PRG's (BT-PRG) efforts and deliberations. This report describes the group's
findings and recommendations for advancing brain tumor-related research. The following section details the process used in
producing this and other PRG reports.
THE PRG PROCESS
The BT-PRG members were selected from among prominent members of the scientific, medical, and advocacy communities and from
industry to represent the full spectrum of scientific expertise required to make comprehensive recommendations for the NCI's
cancer research agenda. The membership was also selected for its ability to take a broad view in identifying and prioritizing
scientific needs and opportunities that are critical to advancing the field of cancer research.
In February 2000, the PRG Leadership finalized an agenda and process for the PRG Planning Meeting. At the Planning Meeting,
participants were identified to take part in a subsequent Roundtable meeting. Topics were identified for Roundtable breakout
sessions to which those participants were ultimately be assigned and for which the PRG members served as co-chairs.
The Brain Tumor PRG Roundtable Meeting (July 2000) brought together approximately 125 leading members of the cancer research
and advocacy communities. These experts met in an open forum in which they formulated key scientific questions and priorities
for the next 5-10 years of brain tumor research. The PRG used input from the Roundtable in delineating and prioritizing recommendations
for research directions, related scientific questions, and resource and infrastructure needs.
NCI and NINDS provided the PRG Roundtable with extensive information about their research programs. This analysis did not
serve as a critical review of either Institute's research program, but rather was used to compare and contrast the Roundtable's
scientific priorities with the research currently being done under the Institutes' auspices. On the basis of this review and
analysis, the PRG recommended a plan of action to ensure that the recommended priority areas are thoroughly addressed. Their
plan is outlined in this report.
DEVELOPMENT OF THE PRG REPORT
After the Roundtable Meeting, an intermediate draft report was prepared, multiple iterations of which were reviewed by the
PRG Leadership and PRG Members. Upon completion of the final draft, the report was submitted for deliberation and acceptance
by the NCI Advisory Committee to the Director and the NINDS Council. The report will be widely disseminated and integrated
into each Institute's planning activities. In Spring 2001, the PRG will meet with the NCI and NINDS Director to discuss the
Institutes' response to the report.
PRG reports on breast, prostate, and colorectal cancer are available on line at http://prg.nci.nih.gov/index.html. Other PRG reports currently in development or being planned include reports on pancreatic cancer; leukemia, lymphoma, and
myeloma; gynecologic cancers; kidney and bladder cancer; stomach and esophageal cancers; liver and bile duct cancers; and
skin cancer.
Report on the Brain Tumor Progress Review Group.
You can learn more about the Brain Tumor Progress Review Group at http://prg.nci.nih.gov/brain/default.html.
Last updated June 25, 2007