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National Lung Screening Trial (NLST)
Basic Trial Information
Objectives
Entry Criteria Disease Characteristics:
Prior/Concurrent Therapy: Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Patient Characteristics: Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Expected Enrollment A total of 50,000 participants will be accrued for this study within 2 years. Outline This is a randomized, multicenter study. Participants are randomized to 1 of 2 screening arms.
Participants in both arms undergo screening initially and then annually for 2 years. Participants will then be contacted annually by mail or telephone for several years. The National Lung Screening Trial (NLST) represents the union of two NCI-sponsored activities, the NCI Lung Screening Study I and the American College of Radiology Imaging Network (ACRIN). For more information, please access the ACRIN trial on Cancer.gov. The protocol ID is ACRIN-6654. Published ResultsGierada DS, Pilgram TK, Ford M, et al.: Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening. Radiology 246 (1): 265-72, 2008.[PUBMED Abstract] Trial Lead Organizations National Cancer Institute
American College of Radiology Imaging Network
Related Information Web site for additional information
Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer. Because all potentially harmful side effects are not known before a trial is conducted, dose and schedule modifications may be required for participants if they develop side effects from the treatment or test. The therapy or test described in this clinical trial is intended for use by clinical oncologists in carefully structured settings, and may not prove to be more effective than standard treatment. A responsible investigator associated with this clinical trial should be consulted before using this protocol. |
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