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Preventing Delayed Nausea in Breast Cancer Patients
Untitled Document
Name of the Trial
Phase III Randomized Study of Different Combinations of Granisetron Hydrochloride,
Dexamethasone, Prochlorperazine, Aprepitant, and Palonosetron Hydrochloride
in Preventing Delayed Nausea in Women Undergoing Chemotherapy for Chemotherapy-Naive
Breast Cancer (URCC-04-02). See the protocol
summary.
Principal Investigator
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Dr. Joseph Roscoe
Principal Investigator |
Dr. Joseph Roscoe, University of Rochester Cancer Center.
Why This Trial Is Important
Nausea is a common side effect of cancer chemotherapy. Severe nausea may keep
patients from consuming enough food and liquids to maintain their energy and
prevent dehydration, and it can lead to disruptions in cancer treatment.
A number of drugs are available to treat and prevent chemotherapy-induced nausea,
but it is unclear which drug or combination of drugs is most effective for patients
experiencing delayed nausea. Delayed nausea is nausea that occurs more than
24 hours after chemotherapy is administered. It is often more severe than the
acute nausea that may occur during chemotherapy, and it may have a different
underlying cause.
In this trial, different combinations of drugs will be tested to see which is
most effective in preventing delayed nausea in women undergoing chemotherapy
for breast cancer.
"Because of the types of drugs they receive, as many as 70 percent of
breast cancer patients undergoing chemotherapy experience nausea," said
Dr. Roscoe, "so we're very interested in finding more effective ways of
preventing and treating nausea in this population.
"This study is part of a line of research our cooperative group has been
conducting into nausea and vomiting," he added, "and, although vomiting
is becoming less of a problem thanks to advances in anti-emetic drugs, delayed
nausea continues to be a very prevalent side effect for women with breast cancer
who undergo chemotherapy."
Who Can Join This Trial
Researchers will enroll 890 women diagnosed with breast cancer that has not
yet been treated with chemotherapy. See the list
of eligibility criteria.
Study Site and Contact Information
Study sites in the United States are recruiting patients for this trial. See
the list
of study contacts or call the NCI's Cancer Information Service at 1-800-4-CANCER
(1-800-422-6237) for more information. The toll-free call is confidential.
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