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Selected Recent Publications

2006

  • Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam L, Dave S, Yang L, Powell J, Staudt LM. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006, in press. Article in PDF format.
  • Shaffer AL, Wright G, Yang L, Ngo V, Lamy L, Lam L, Davis RE, Staudt LM. A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunol Rev 2006, in press. Article in PDF format.

2005

  • Staudt LM , Dave, S. The biology of human lymphoid malignancies revealed by gene expression profiling. Advances in Immunology 2005, 87:163-208. Article in PDF format.
  • Bea S, Zettl A, Wright G, Salaverria I, Jehn J, Moreno V, Burek C, Ott G, Puig X, Yang L, Lopez-Guillermo A, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Gascoyne RD, Connors JM, Grogan TM, Braziel R, Fisher RI, Smeland EB, Kvaloy S, Delabie J, Simon R, Powell J, Wilson WH, Jaffe ES, Montserrat E, Muller-Hermelink HK, Staudt LM, Campo E, Rosenwald A. Diffuse large B cell lymphoma subtypes have distinct genetic profiles that influence tumor biology and improve gene expression-based survival prediction. Blood 2005 106:3183-90. Article in PDF format.
  • Fu K, Weisenburger DD, Greiner TC, Dave S, Chiorazzi M, Wright G, Gesk S, Siebert R, De Jong D, Jaffe ES, Delabie J, Ott G, Wilson W, Braziel RM, Dave BJ, Sanger WG, Smith LM, MŸller-Hermelink HK, Campo E, Gascoyne RD, Rosenwald A, Staudt LM, Chan WC. Cyclin D1-Negative Mantle Cell Lymphoma: A Gene Expression Profiling, Genetic and Clinicopathological Study. Blood 2005106:4315-21. Article in PDF format.
  • Lam LT, Davis RE, Pierce J, Hepperle m, Xu Y, Hottelet M, Nong Y, Wen D, Adams J, Dang L, Staudt LM. Small molecule inhibitors of I_B-Kinase are selectively toxic for subgroups of diffuse large B cell lymphoma defined by gene expression profiling. Clinical Cancer Research 2005 11:1-13. Article in PDF format.

2004

  • Rosenwald A, Chuang EY, Davis RE, Wiestner A, Alizadeh AA, Botstein D, Brown PO, Mitchell JB, Marti GE, Fowler DH, Wilson WH, Staudt LM. Fludarabine treatment of chronic lymphocytic leukemia patients induces a p53-dependent gene expression response. Blood 2004 104:1428-1434. Article in PDF format.
  • Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee A-H, Qian S-B, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW, Calame K, Glimcher LH, Staudt LM. XBP acts downstream of Blimp- to expand the secretory apparatus, promote organelle biogenesis, and increase protein synthesis during plasma cell differentiation. Immunity 2004, 21:81:93. Article in PDF format.
  • Hurt EM, Wiestner A, Rosenwald A, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 2004 5:191-199. Article in PDF format.
  • Dave S, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel R, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp P, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, and Staudt LM. Survival following diagnosis of follicular lymphoma is predicted by molecular features of non-malignant tumor-infiltrating immune cells. New Engl J Med 2004 351:2159-2169. Article in PDF format.

2003

  • Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell, 2003, 3:185-197. Article in PDF format.
  • Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA, Davis Z, Stetler-Stevenson M, Raffeld M, Arthur DC, Marti GE, Wilson WH, Hamblin TJ, Oscier DG, Staudt LM. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome and distinct gene expression profile. Blood, 2003, 101:4944-4951. Article in PDF format.
  • Wright GE, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci 2003, 100:9991-9996. Article in PDF format.
  • Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med 2003 348:1777-85. Article in PDF format.
  • Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao H, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel1 R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003, 198:1-12. Article in PDF format.

2002

  • Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, Lopez-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy of diffuse large B-cell lymphoma. N Engl J Med 2002,346:1937-1947. Article in PDF format.
  • Shaffer AL, Lin K-I, Yu X, Hurt EM, Rosenwald A, Giltnane JM, Zhao H, Calame K, Staudt LM. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity, 2002, 17:51-62. Article in PDF format.
  • Shaffer AL, Rosenwald A, Staudt LM. Lymphoid malignancies: the dark side of mature B cell differentiation and activation. Nature Reviews Immunology 2002, 2:1-13. Article in PDF format.
  • Staudt LM, Wilson WH. Focus on lymphoma. Cancer Cell 2002, 2:363-366. Article in PDF format.

2001

  • Davis RE, Brown KD, Siebenlist U and Staudt LM. Constitutive Nuclear Factor kB Activity is Required for Survival of Activated B Cell-like Diffuse Large B Cell Lymphoma Cells. J. Exp. Med. 2001 Dec. 17. 194 (12) 1861-1874. Article in PDF format.
  • Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol. 2001, 2:316-24. Article in PDF format.
  • Lloyd T Lam, Oxana K Pickeral, Amy C Peng, Andreas Rosenwald, Elaine M Hurt, Jena M Giltnane, Lauren M Averett, Hong Zhao, R Eric Davis, Mohan Sathyamoorthy, Larry M Wahl, Eric D Harris, Judy A Mikovits, Anne P Monks, Melinda G Hollingshead, Edward A Sausville, Louis M Staudt. Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biology. 13 Sept. 2001. Article on-line and in PDF format.
  • Ma, C and Staudt LM. Molecular definition of the germinal centre stage of B-cell differentiation. Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29. 356(1405):83-9.
  • Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, Yang L, Pickeral OK, Rassenti LZ, Powell J, Botstein D, Byrd JC, Grever MR, Cheson BD, Chiorazzi N, Wilson WH, Kipps TJ, Brown PO, Staudt L . Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia. J. Exp. Med. 2001 Dec 3. 194(11) 1639-1647. Article in PDF format.
  • Shaffer AL, Rosenwald A, Hurt EM, Giltnane JM, Lam LT, Pickeral OK and Staudt, LM. Immunity. September, 2001, 15: 375-385. Article in PDF format.
  • Staudt, LM. Gene expression physiology and pathophysiology of the immune system. Trends Immunol. 2001, 22:35-40. Article in PDF format.

2000

  • Alizadeh A, Eisen M, Davis RE, Ma CA, Lossos I, Rosenwald A, Boldrick J, Sabet H, Tran T, Yu X, Powell J, Yang L, Marti G, Moore T, Hudson J, Chan WC, Greiner TC, Weissenberger DD, Armitage JO, Levy R, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403:503-511. Article in PDF format.
  • Alizadeh AA, Staudt LM. Genomic-scale gene expression profiling of normal and malignant immune cells. Curr Opin Immunol 2000, 12:219-225. Article in PDF format.
  • Hastie T, Tibshirani R, Eisen MB, Alizadeh A, Levy R, Staudt L, Chan WC, Botstein D, Brown P. 'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biology 2000, 1:3.1-3.21. Article on-line and in PDF format.
  • Lossos IS, Alizdeh AA, Eisen MB, Chan WC, Brown PO, Botstein D, Staudt LM, Levy R. Ongoing immunoglobulin heavy chain somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad Sci U S A, 2000, 97:10209-13. Article in PDF format.
  • Meffre E, Davis E, Schiff C, Cunningham-Rundles C, Ivashkiv LB, Staudt LM, Young JW, Nussenzweig MC. Circulating human B cells that express surrogate light chains and edited receptors. Nat Immunol. 2000, 1:207-13. Article in PDF format.
  • Shaffer AL, Yu X, He Y, Boldrick J, Chan E, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation and cell cycle control. Immunity 2000, 13:1-20. Article in PDF format.
  • Staudt LM. The molecular and cellular origins of Hodgkin's disease. J Exp Med, 2000; 191:207-212. Article in PDF format.
  • Staudt LM. The expression of the genome during immune responses. Curr Opin Immunol 2000, 12:199-200. Article in PDF format.
  • Staudt LM. Gene expression physiology and pathophysiology of the immune system. Immunology Today 2000, in press.
  • Staudt LM, Brown PO. Genomic views of the immune system. Annual Reviews of Immunology, 2000, 18:829-859. Article in PDF format.

    1996-1999

  • Allman D, Jain A, Dent A, Maile R, Selvaggi T, Kehry MR, Staudt LM. BCL-6 expression during B cell activation. Blood 1996;87:5257-5268.
  • Alizadeh A, Eisen M, Brown PO, Staudt LM. Probing Lymphocyte Biology by Genomic-scale Gene Expression Analysis. J Clin Immunol, 1998;18:373-379.
  • Alizadeh A, Eisen M, Davis RE, Ma CA, Sabet H, Tran T, Powell JI, Yang L, Marti GE, Moore DT, Hudson JR, Chan WC, Greiner T, Weisenberger D, Armitage JO, Lossos I, Levy R, Botstein D, Brown PO, Staudt LM. The Lymphochip: A specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harbor Symposium on Quantitative Biology, 1999; 64:71-78
  • Dent AL, Doherty, TM, Paul WE, Sher, A, Staudt LM. BCL-6-deficient mice reveal an IL-4-independent STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J Immunol 1999; 163:2098-2103.
  • Dent AL, Hu-Li J, Paul WE, Staudt LM. TH2-type Inflammation in the Absence of IL-4 and STAT6. Proc Natl Acad Sci, 1998; 95:13823-13828.
  • Dent AL, Shaffer A, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression and germinal center formation by BCL-6. Science 1997;276:589-592.
  • Iyer, VR, Eisen, MD, Ross, DT, Schuler, G, Moore, T, Lee, J, Trent, JM, Staudt, LM, Hudson, J, Boguski, M, Lashkari, D, Shalon, D, Botstein, D, Brown, PO The transcriptional response of human fibroblasts to serum. Science 1999;283:83-87.
  • Seyfert V, Allman D, He Y, Staudt LM. Transcriptional repression by the proto-oncogene BCL-6. Oncogene 1996;12:2331-2342.
  • Staudt LM, Dent AL, Shaffer AL, Yu X. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. Int Rev Immunol. 1999;18:381-403.

 

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