Biosketch

Harvey G. Klein graduated magna cum laude from Harvard College and earned his medical degree from Johns Hopkins School of Medicine. After an internship, residency and fellowship in hematology at Hopkins, Dr. Klein came to the National Institutes of Health in 1973, becoming chief of the Clinical Center’s Department of Transfusion Medicine in 1984. He maintains his ties with Hopkins as a visiting professor in pathology and medicine.

Dr. Klein is known nationally and internationally for his expertise in blood transfusion. He is widely published on such topics as transfusion-transmitted disease, the management of immunosuppressive effects of blood transfusion, and the impact of biotechnology on transfusion medicine. He co-authored the eleventh edition of Mollison’s textbook, Blood Transfusion in Clinical Medicine, and has held editorial roles with several publications, including Blood, Transfusion, Transfusion Medicine Reviews, and the Journal of Clinical Apheresis .

Dr. Klein has an extensive list of professional activities that includes serving on the Institute of Medicine Blood Safety Forum, the Secretary’s Advisory Committee on Blood Safety and Availability, the WHO Committee on Standardization and the FDA Blood Products Advisory Committee; chairing the US Pharmacopoeia Blood and Blood Products Committee and the American Red Cross Medical Advisory Committee; and serving as president of the American Association of Blood Banks and the National Marrow Donor Program Council.

Selected Honors and Awards

Emily Cooley Award of the American Association of Blood Banks, 2001; NIH Director’s Award, 2000; HHS Secretary’s Distinguished Services Award, 2000; Cohn de Laval Medal, World Apheresis Association, 1996; Allen Latham Award, European Society for Haemapheresis, 1995; John B. Alsever Award for contributions to the blood banking sciences, 1993; NIH Clinical Center Director’s Award, 1992; meritorious service medal, Public Health Service, 1989; PHS Equal Opportunity Achievement Award, 1985; PHS commendation medal, 1980

Selected Publications

BOOKS

Klein HG and Anstee DJ. Mollison’s Blood Transfusion in Clinical Medicine. 11th Edition.Blackwell, London, 2005

SELECTED BOOK CHAPTERS

Klein, HG. Immunohematology and Blood Transfusion. In Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds): Harrison's Principles of Internal Medicine, McGraw-Hill Inc, New York l993: p 2377.

Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Schwartz BD, Shearer WT, Strober W (eds): Clinical Immunology: Principles and Practice. Mosby, St. Louis 1995, p2220-2228.

Klein HG. The immunomodulatory effects of blood transfusion. In: Petz LD, Swisher S, Kleinman S, Spence R, Strauss RG (eds): Clinical Practice of Transfusion Medicine. Churchill Livingstone, New York 1996, p 59-70.

Klein HG. Continuing issues regarding transfusion and coagulation factor-acquired HIV infection. In: Pizzo PA, Wilfert CM (eds); Pediatric AIDS. (3rd Edition) Baltimore, Williams and Wilkins, 1998.

Conry-Cantilena, Klein, HG. Hemochromatosis subjects as blood and tissue donors.In: Barton JC and Edwards CO, (eds); Hemochromatosis. Cambridge University Press, Cambridge 2000: p564-73.

Klein HG and Higgins MJ. Use of Blood components in the Intensive care Unit. In:Parrillo JE and Dellinger RP, (eds); Critical care Medicine. Mosby, Philadelphia 2001, p1416-1438.

Griffith L, Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Kotzin B, Shearer WT, Schroeder H (eds): Clinical Immunology: Principles and Practice. Churchill Livingstone, London 2001, p127.1-127.10.

Lazarus EF, Klein HG. Hemapheresis and cellular therapy. In: Hoffman R. Benz EJ, Shattil S, Furie B, Cohen HJ, Silberstein LE, McGlave P (eds): Hematology: Principles and Practice. Churchill Livingstone Inc.: New York 2005, p2481-92.

Alvandi F, Klein HG. Blood Transfusion. In Clinical Hematology , Young NS, Gerson SL, High KA (editors). Elsevier, Philadelphia, 2006.

SELECTED JOURNAL ARTICLES

Klein HG, Aledort LM, Bouma BN., et al. A Cooperative Study for the Detection of the Carrier State of Classic Hemophilia. N Engl J Med l977; 296:959-962.

Miller DM, Winslow RM, Klein HG, Wilson KC, Statham NJ, Brown FL, Fulmer J. Improved Exercise Performance after Exchange Transfusion in Subjects with Sickle Cell Anemia. Blood l980;56:ll27-32.

Bracey A, Klein HG, Chambers S, Corash L. Simplified Selective Isolation of Young Red Cells for Chronic Transfusion Support. Blood l983; 6l:l068-l07l.

Carter CS, Leitman SF, Cullis H, Muul LM, Nason - Burchenal K, Rosenberg SA, Klein HG. Use of a continuous flow cell separator in density gradient isolation of lymphocytes. Transfusion l987; 27:362-365.

Leitman SF, Klein HG, Melpolder JJ, Shih JW, Read EJ, Harvarth L, Darr F, Foy JL, Alter HJ. Clinical implications of positive tests for antibodies to human immunodeficiency virus type 1 in asymptomatic blood donors. N Engl of Med l989; 32l:9l7-23.

Alter HJ, Epstein JS, Swenson SG, Van Raden MA, Klein HG, Ward JW, Kaslow RA, Menitove JE, Sandler SG, Sayers MH, Hewlett IK, Chernoff AI. Prevalence of Human Immunodeficiency Virus Type 1 (HIV-l) p24 antigen in U.S. Blood Donor: Assessment of Efficacy for Blood Donor Screening. N Engl J Med l990, 323:l3l2-l7.

Lee JH, Leitman SF, Klein HG. A controlled comparison of the efficacy of hetastarch and pentastarch in granulocyte collections of centrifugal leukapheresis. Blood 1995; 86:4662-6.

Leitman SF, Browning JM, Yau YY, Mason G, Klein HG, Conry-Cantilena C, Bolan CD. Hemochromatosis subjects as allogeneic blood donors: a prospective study. Transfusion 2003; 43:1538-44.

Klein, HG. Pathogen Inactivation: Cleansing the blood supply. J. Int. Med. 2005; 257:224-237

Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007;370:415-426

Klein HG, Anderson D, Bernardi MJ, Cable R, Carey W, Hoch JS, Robitaille N, Sivilotti ML, Smaill F. Pathogen inactivation: making decisions about new technologies - report of a consensus conference. Transfusion 2007; 47: 2338-2347

Deola S, Panelli MC, Maric D, Dmitrieva N, Voss C, Stroncek DF, Klein HG, Wang E Marincola FM. Helper" B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27-CD70 interactions. J. Immunol 2008; 180:1362-72