Biosketch

Dr. Suffredini came to the Clinical Center in 1984 as a medical staff fellow in the Critical Care Medicine Department. He has held his current position as senior investigator since 1989. He is also on the medical staff of the Washington Hospital Center.

Dr. Suffredini completed his undergraduate studies at Boston University. He attended the University of Rome School of Medicine and graduated from the University of Connecticut School of Medicine. He then completed an internship and residency in internal medicine at the Medical College of Virginia, Richmond, and a fellowship in Critical Care Medicine at the University Health Center of Pittsburgh.

Dr.Suffredini's research focuses on the investigation of innate immunity and its regulatory mechanisms in pulmonary inflammation, sepsis, and septic shock. He is a co-founder of the Functional Genomics Section and director of the Clinical Proteomics Group in the Critical Care Medicine Department.

Honors and Awards

NIH Director’s Award 2007, NIH Clinical Center Director’s Award, 2004, 1999, 1998; President’s Award: Society of Critical Care Medicine. 1999, 1998, 1997, 1996; Fellows Award for Research Excellence, NIH Clinical Center, 1998, 1997; American Federation for Clinical Research, Henry Christian Award for Excellence in Research Presentation, 1990; USPHS Outstanding Unit Citation, 2004, 1994, 1991; USPHS Commendation, 1997, 1994, 1991; USPHS Unit Commendation, 1991

Selected Publications

BOOKS and BOOK CHAPTERS

Susla GM, Suffredini AF, McAreavey D, Solomon M, Hoffman WD, Nyquist P, Ognibene FP, Shelhamer JH, Masur H. Handbook of Critical Care Drug Therapy, 3rd edition, Lippincott Williams and Wilkins, Baltimore, 2006

JOURNAL ARTICLES

Fiuza C, Bustin M, Talwar S, Tropea M, Gerstenberger E, Shelhamer JH, Suffredini AF. Inflammatory promoting activity of HMGB1 on human microvascular endothelial cells. Blood 2003; 101:2652-2660.

Igarashi T, Donau OK, Imamichi H, Dumaurier MJ, Sadjadpour R, Plishka RJ, Buckler-White A, Buckler C, Suffredini AF, Lane HC, Moore JP, Martin MA. Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages. J Virol 2003;77:13042-52.

Jison ML, Munson PJ, Barb JJ, Suffredini AF, Talwar S, Logun C, Raghavachari N, Beigel JH, Shelhamer JH, Danner RL, Gladwin MT. Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease. Blood 2004; 104:270; 270-280.

Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP Jr. Multiplex bead assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers. Cytometry 2004:61B:35-39.

Gorak E, Geller N, Srinivasan R, Chakrabarti S, Barrett AJ, Suffredini AF, and Childs RW. Decreased survival in patients with pulmonary engraftment syndrome following nonmyeloablative allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2005;11:542-50.

Pawliczak R, Logun C, Madara P, Barb J, Suffredini AF, Munson PJ, Danner RL, Shelhamer JH. The influence of interferon gamma on gene expression in normal human bronchial epithelial cells: modulation of interferon gamma effects by dexamethasone. Physiol Genomics. 2005;23:28-45. Epub 2005 Jun 28.

S Talwar, PJ Munson, C Fiuza, Barb J, Cintron P, Logun C, Reda D, RL Danner, AF Suffredini. Gene expression profiling of peripheral blood cells after endotoxin challenge in humans. Physiol Genomics. 2006 ;25:203-15. Epub 2006 Jan 10

De Torre C, Ying S-X, Munson PJ, Meduri GU, Suffredini AF. Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage. Proteomics 2006;6:3949 – 57. Epub 2006 June 12.

Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Munson PJ, Kato G, Morris S, and Gladwin MT. Amplified expression profiling of platelet transcriptome reveals global activation of arginine degradation pathways in patients with sickle cell disease. Circulation. 2007;115:1551-62. Epub 2007 Mar 12.

Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Klein HG, Schechter A, Banks SM, Eichacker PQ, and Natanson C. Therapeutic misassignment: a potential confounder of randomized trials investigating routinely titrated therapies. Crit Care Med. 2007;35:1509-1516.