Personalizing Cancer Prevention

 


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Air date: Wednesday, April 16, 2008, 3:00:00 PM
Category: Wednesday Afternoon Lectures
Runtime: 72 minutes
NLM Title: Personalizing cancer prevention [electronic resource] / Alice S. Whittemore.
Series: NIH Robert S. Gordon, Jr. lecture
Author: Whittemore, Alice.
National Institutes of Health (U.S.)
Publisher: [Bethesda, Md. : National Institutes of Health, 2008]
Other Title(s): NIH Robert S. Gordon, Jr. lecture
Abstract: (CIT): In this talk I will discuss some of the paradoxes and problems in personalizing the prevention of cancer and other chronic diseases. For example, how will individuals handle the information they receive? What are the emotional consequences of learning that you are at increased risk of a life-threatening disease? How can patients and their physicians understand and balance the risks and benefits of any given preventive strategy? What epidemiologic data are needed to help them? From a public health perspective, one might ask how individual risk prediction might be used to decrease the disease burden of a population. The attraction of personalized prevention is based on the premise that individuals have a broad spectrum of risks for a given disease, and that most of the disease burden is borne by a small subset of identifiable "high-risk" individuals. According to this premise, identifying the high-risk individuals would enable us to focus screening and chemo-prevention on those for whom it would be most effective. Is the premise valid? Some have argued against it, noting examples in which individuals deemed "high-risk" account for only a small fraction of a given disease. Even if valid, the premise involves the paradox that many individuals must undergo a given preventive strategy so that a handful can receive the benefit. I will illustrate these issues with examples from our current attempts to prevent breast and prostate cancer.
Subjects: Genetic Predisposition to Disease
Neoplasms--epidemiology
Neoplasms--prevention & control
Neoplasms--psychology
Risk Assessment
Publication Types: Government Publications
Lectures
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NLM Classification: QZ 200
NLM ID: 101473090
CIT File ID: 14436
CIT Live ID: 6219
Permanent link: http://videocast.nih.gov/launch.asp?14436

 

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