Compressed gases can be hazardous because each cylinder contains large amounts of energy and may also have high flammability and toxicity potential.

The following is a list of recommendations for storage, maintenance, and handling of compressed gas cylinders:

• Make sure the contents of the compressed gas cylinder are clearly stenciled or stamped on the cylinder or on a durable label.
• Do not identify a gas cylinder by the manufacturer’s color code.
• Never use cylinders with missing or unreadable labels.
• Check all cylinders for damage before use.
• Be familiar with the properties and hazards of the gas in the cylinder before using.
• Wear appropriate protective eyewear when handling or using compressed gases.
• Use the proper regulator for each gas cylinder.
• Do not tamper with or attempt to repair a gas cylinder regulator.
• Never lubricate, modify, or force cylinder valves.
• Open valves slowly using only wrenches or tools provided by the cylinder supplier directing the cylinder opening away from people.
• Check for leaks around the valve and handle using a soap solution, "snoop" liquid, or an electronic leak detector.
• Close valves and relieve pressure on cylinder regulators when cylinders are not in use. Label empty cylinders "EMPTY" or "MT" and date the tag; treat in the same manner that you would if it were full.
• Always attach valve safety caps when storing or moving cylinders.
• Transport cylinders with an approved cart with a safety chain; never move or roll gas cylinders by hand.
• Securely attach all gas cylinders (empty or full) to a wall or laboratory bench with a clamp or chain, or secure in a metal base in an upright position.
• Store cylinders by gas type, separating oxidizing gases from flammable gases by either 20 feet or a 30-minute firewall that is 5 feet high.
• Store gas cylinders in cool, dry, well-ventilated areas away from incompatible materials and ignition sources.
• Do not subject any part of a cylinder to a temperature higher than 125 °F or below 50 °F.
• Store empty cylinders separately from full cylinders.