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Depression and HCV TreatmentDepression is a common comorbidity of HIV and HCV, and it is common among drug users.152-157 Treating depression among PLWHA has improved adherence to antiretroviral therapy158 and is a key management strategy for interferon-induced depression. Schaefer and colleagues reported that patients with a psychiatric history were successfully treated for HCV when a pretreatment psychiatric evaluation and ongoing multidisciplinary care were offered with HCV treatment.110 Some clinicians and patients prefer to start antidepressants prior to HCV treatment, whereas others favor antidepressant use only if it becomes necessary. Because treatment discontinuations often occur due to psychiatric adverse events, it is sensible to avert such events when possible by incorporating mental health care into HCV treatment planning.
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