NCBI
PubMed
A service of the
U.S. National Library of Medicine
and the
National Institutes of Health
My NCBI
[Sign In]
[Register]
All Databases
PubMed
Nucleotide
Protein
Genome
Structure
OMIM
PMC
Journals
Books
Search
Database name
PubMed
Protein
Nucleotide
GSS
EST
Structure
Genome
Books
CancerChromosomes
Conserved Domains
dbGaP
3D Domains
Gene
Genome Project
GENSAT
GEO Profiles
GEO DataSets
HomoloGene
Journals
MeSH
NCBI Web Site
NLM Catalog
OMIA
OMIM
PMC
PopSet
Probe
Protein Clusters
PubChem BioAssay
PubChem Compound
PubChem Substance
SNP
SRA
Taxonomy
ToolKit
ToolKitAll
UniGene
UniSTS
for
Search term
Go
Clear
Advanced Search
Limits
Preview/Index
History
Clipboard
Details
Display
Summary
Brief
Abstract
AbstractPlus
Citation
MEDLINE
XML
UI List
LinkOut
ASN.1
Related Articles
Cited in Books
CancerChrom Links
Domain Links
3D Domain Links
dbGaP Links
GEO DataSet Links
Gene Links
Gene (OMIM) Links
Gene (GeneRIF) Links
Genome Links
Project Links
GENSAT Links
GEO Profile Links
HomoloGene Links
Nucleotide Links
Nucleotide (RefSeq) Links
Nucleotide (Weighted) Links
EST Links
EST (RefSeq) Links
GSS Links
GSS (RefSeq) Links
OMIA Links
OMIM (calculated) Links
OMIM (cited) Links
BioAssay Links
Compound Links
Compound (MeSH Keyword)
Compound (Publisher) Links
Substance Links
Substance (MeSH Keyword)
Substance (Publisher) Links
PMC Links
Cited in PMC
PopSet Links
Probe Links
Protein Links
Protein (RefSeq) Links
Protein (Weighted) Links
Protein Cluster Links
Cited Articles
SNP Links
SNP (Cited)
Structure Links
Taxonomy via GenBank
UniGene Links
UniSTS Links
Show
5
10
20
50
100
200
500
Sort By
Pub Date
First Author
Last Author
Journal
Title
Send to
Text
File
Printer
Clipboard
Collections
E-mail
Order
All: 1
Review: 0
Click to change filter selection through MyNCBI.
1:
JAMA.
1992 Aug 19;268(7):877-81.
Related Articles
,
Links
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.
Stampfer MJ
,
Malinow MR
,
Willett WC
,
Newcomer LM
,
Upson B
,
Ullmann D
,
Tishler PV
,
Hennekens CH
.
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
OBJECTIVE--To assess prospectively the risk of coronary heart disease associated with elevated plasma levels of homocyst(e)ine. DESIGN--Nested case-control study using prospectively collected blood samples. SETTING--Participants in the Physicians' Health Study. PARTICIPANTS--A total of 14,916 male physicians, aged 40 to 84 years, with no prior myocardial infarction (MI) or stroke provided plasma samples at baseline and were followed up for 5 years. Samples from 271 men who subsequently developed MI were analyzed for homocyst(e)ine levels together with paired controls, matched by age and smoking. MAIN OUTCOME MEASURE--Acute MI or death due to coronary disease. RESULTS--Levels of homocyst(e)ine were higher in cases than in controls (11.1 +/- 4.0 [SD] vs 10.5 +/- 2.8 nmol/mL; P = .03). The difference was attributable to an excess of high values among men who later had MIs. The relative risk for the highest 5% vs the bottom 90% of homocyst(e)ine levels was 3.1 (95% confidence interval, 1.4 to 6.9; P = .005). After additional adjustment for diabetes, hypertension, aspirin assignment, Quetelet's Index, and total/high-density lipoprotein cholesterol, this relative risk was 3.4 (95% confidence interval, 1.3 to 8.8) (P = .01). Thirteen controls and 31 cases (11%) had values above the 95th percentile of the controls. CONCLUSIONS--Moderately high levels of plasma homocyst(e)ine are associated with subsequent risk of MI independent of other coronary risk factors. Because high levels can often be easily treated with vitamin supplements, homocyst(e)ine may be an independent, modifiable risk factor.
Publication Types:
Research Support, U.S. Gov't, P.H.S.
PMID: 1640615 [PubMed - indexed for MEDLINE]
Display
Summary
Brief
Abstract
AbstractPlus
Citation
MEDLINE
XML
UI List
LinkOut
ASN.1
Related Articles
Cited in Books
CancerChrom Links
Domain Links
3D Domain Links
dbGaP Links
GEO DataSet Links
Gene Links
Gene (OMIM) Links
Gene (GeneRIF) Links
Genome Links
Project Links
GENSAT Links
GEO Profile Links
HomoloGene Links
Nucleotide Links
Nucleotide (RefSeq) Links
Nucleotide (Weighted) Links
EST Links
EST (RefSeq) Links
GSS Links
GSS (RefSeq) Links
OMIA Links
OMIM (calculated) Links
OMIM (cited) Links
BioAssay Links
Compound Links
Compound (MeSH Keyword)
Compound (Publisher) Links
Substance Links
Substance (MeSH Keyword)
Substance (Publisher) Links
PMC Links
Cited in PMC
PopSet Links
Probe Links
Protein Links
Protein (RefSeq) Links
Protein (Weighted) Links
Protein Cluster Links
Cited Articles
SNP Links
SNP (Cited)
Structure Links
Taxonomy via GenBank
UniGene Links
UniSTS Links
Show
5
10
20
50
100
200
500
Sort By
Pub Date
First Author
Last Author
Journal
Title
Send to
Text
File
Printer
Clipboard
Collections
E-mail
Order
About Entrez
Text Version
Entrez PubMed
Overview
Help
|
FAQ
Tutorials
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
Special Queries
LinkOut
My NCBI
Related Resources
Order Documents
NLM Mobile
NLM Catalog
NLM Gateway
TOXNET
Consumer Health
Clinical Alerts
ClinicalTrials.gov
PubMed Central
Write to the Help Desk
NCBI
|
NLM
|
NIH
Department of Health & Human Services
Privacy Statement
|
Freedom of Information Act
|
Disclaimer