NIH Clinical Center: FY 2008 Bench-to-Bedside Proposals

FY 2008 Bench-to-Bedside Funded Projects

GENERAL CATEGORY:

Teams	Projects	Investigators
NCI NIAID Ludwig Institute for Cancer Research Weill Medical College Cornell	Targeting cancer-testis gene expression for lung cancer therapy	D. Schrump, MD, NCI; V. Lobanenkov, PhD, NIAID; L. Old, MD, Ludwig Institute for Cancer Research; and N. Altorki, MD, Weill Med College, Cornell
NINR U of MD	Molecular mechanisms of glial cell modulation of chemotherapy-induced painful peripheral neuropathy	X. Wang, MD, PhD, NINR; S. Dorsey, RN, PhD, and C. Renn, RN, PhD, U of MD

AIDS CATEGORY:

Teams	Project	Investigators
NCI University of California, San Diego	New strategies to decrease and eradicate HIV-1 reservoirs	F. Maldarelli, MD, PhD, NCI; E. Reid, MD, UCSD
NICHD Case Western Reserve	HIV-1 suppression by Acyclovir in patients coinfected with human herpesviruses from basic mechanism to clinical application	L. Margolis, PhD, NICHD; M. Lederman, MD, Case Western
NIAID NHLBI, Children’s National Medical Center NC	Non-invasive cardiac 3T MRI for evaluation of premature coronary artery disease and myocardial dysfunction in adolescents and young adults with HIV acquired in infancy and childhood	C. Hadigan, MD, MPH, NIAID; A. Gharib, MD, NHLBI; R. Cross, MD, MS, CNMC; S. Clauss, MD, CNMC

AIDS/MINORITY HEALTH CATEGORY:

Teams	Project	Investigators
NIAID Johns Hopkins University Uganda (Makere Medical School, Mulago Hospital)	Hepatitis B and HIV co-infection in Uganda	T. Quinn, MD and L. Stabinski, MD, MPH, NIAID; C. Thio, MD and G. Kirk, MD, MPH, PhD, JHU
NCI FDA University of Washington	Development and evaluation of a nanoparticle-based HIV-1 p24 antigen assay for monitoring therapy in resource limited settings	F. Maldarelli, MD, PhD, NCI; Hewlett, PhD, FDA; L. Frenkel, MD, U of WA

MINORITY HEALTH & HEALTH DISPARITIES CATEGORY:

Teams	Project	Investigators
NIDDK University of Michigan	Toward molecular-marker based management of diabetic nephropathy in Pima Indians	R. Nelson, MD, PhD, NIDDK; M. Kretzler, MD, U MI

RARE DISEASES CATEGORY:

Teams	Project	Investigators
NHGRI University of South Carolina University of Texas-MD Anderson	Predicting the response to treatment using gene mutation profiling in metastatic melanoma patients	Y. Samuels, PhD, NHGRI; P. Buckhaults, PhD, U of SC; P. Hwu, MD, U of TX-MD Anderson
NHLBI NIH Clinical Center	Graft-Versus-Host Disease: novel cellular therapy using selective thawing of umbilical cord blood to obtain an aliquot for ex-vivo natural killer cell expansion and infusion following allogeneic hematopoietic stem cell transplantation	R. Childs, MD, NHLBI; S. Vasu, MD, CC
NIH Clinical Center NHLBI INOVA Fairfax Hosp	Evaluation of the platelet transcriptome expression profile in pulmonary arterial hypertension	R.F. Machado, MD (Clinical /Translational) and N. Raghavachari, PhD, NHLBI (Basic Science); S. Nathan, MD, INOVA
NHLBI Harvard Temple University NIH Clinical Center	Characterization of Jak/Stat activation in patients with monosomy 7 and the development of targeted therapy for patients using a Jak2 inhibitor	E. Sloand, MD and N. Young, MD, NHLBI; J. Groopman, MD, Harvard
NHLBI Imperial College, London	Development of immunotherapeutic strategies to overcome tolerance in leukemia	A. J. Barrett, MD, NHLBI; K. Rezvani, MD, PhD, Imperial College School of Med
NIAID NCI	Recombinant human IL-& (CYT107) as immunomodulatory therapy for idiopathic CD4 lymphopenia: a phase I/IIA open-label pilot study	J. Brenchley, PhD and I. Sereti, MD, MHS, NIAID

WOMEN'S HEALTH CATEGORY:

Teams

Project

Investigators

NHLBI
NCI

Immunogenicity of quadrivalent human papilloma virus vaccine (HPV Types 6, 11, 16, 18) in recipients of reduced intensity hematologic stem cell transplantation (HSCT)

Bedside: A. Chenoy, MD, NHLBI and P. Stratton, MD, NICHD

PBench: L. Pinto, MD and L. Wood, MD, NCI

NICHD
NIDDK
Sackler School of Med, Tel Aviv, Israel

Histaminergic pathways and energy intake in obese women

J. Yanovski, MD, PhD, L. Yanoff, MD, and C. Cropp, PharmD, NICHD