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Genetics of Colorectal Cancer (PDQ®)
Health Professional Version   Last Modified: 12/19/2008



Purpose of This PDQ Summary






Introduction






Colon Cancer Genes






Genetic Polymorphisms and Colorectal Cancer Risk






Major Genetic Syndromes






Psychosocial Issues in Hereditary Colon Cancer Syndromes: Lynch Syndrome and Familial Adenomatous Polyposis






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Changes to This Summary (12/19/2008)






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Purpose of This PDQ Summary

This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the genetics of colorectal cancer. This summary is reviewed regularly and updated as necessary by the Cancer Genetics Editorial Board.

The following information is included in this summary:

  • Family history and other risk factors for colorectal cancer.
  • Primary prevention of familial colorectal cancer.
  • Major genes and genetic polymorphisms associated with colorectal cancer risk.
  • Genetic testing, screening, and risk modification for hereditary colorectal cancer.
  • Psychosocial issues associated with hereditary colorectal cancer and genetic testing.

The summary also contains level-of-evidence designations. These designations are intended to help readers assess the strength of the evidence in relation to specific studies or strategies. A description of how level-of-evidence designations are made is described in detail in the PDQ summary Cancer Genetics Overview.

This summary is intended to provide clinicians a framework for discussing genetic testing, screening, and risk modification options with individuals at risk for hereditary colorectal cancer, as well as for making referrals to cancer risk counseling services. It does not provide formal guidelines or recommendations for making health care decisions. Information in this summary should not be used as a basis for reimbursement determinations.

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