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Glucocorticoid Receptors and the Immune System![]() John A. Cidlowski, Ph.D.
Principal Investigator Tel (919) 541-1564 Fax (919) 541-1367 cidlows1@niehs.nih.gov P.O. Box 12233 Mail Drop F3-07 Research Triangle Park, North Carolina 27709 Delivery Instructions Research SummarySteroid hormones regulate tissue-specific gene expression in animals via receptor dependent intracellular signal transduction pathways. These receptors, when activated by the appropriate ligands, both activate and repress the transcription of subsets of genes in target cells, which results in altered gene expression and altered cellular function. The Molecular Endocrinology Group is particularly interested in glucocorticoid receptors and their actions on the immune system because they reflect the primary response to environmental stress.
Major areas of research:
Current projects:
John A. Cidlowski, Ph.D., heads the Molecular Endocrinology Group within the Laboratory of Signal Transduction (LST), and is Chief of the LST. He received his Ph.D. in 1975 from Medical College of Georgia in Endocrinology. He has published over 250 peer-reviewed articles in leading biomedical journals, as well as several book chapters. He served as Professor of Physiology and Biochemistry at University of North Carolina at Chapel Hill before joining the NIEHS in 1995. |
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