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Addressing the Global Challenge of Cancer




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Research Areas and Partnering Nations






Introduction






Understanding the Causes and Mechanisms of Cancer






Accelerating Progress in Cancer Prevention






Improving Early Detection and Diagnosis






Developing Effective and Efficient Treatments






Understanding the Factors that Influence Outcomes






Improving the Quality of Cancer Care






Improving Quality of Life






Improving Cancer Communications






Scientist Exchanges and Training Programs






Building the Capacity and Infrastructure



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Past Highlights
Building the Capacity and Infrastructure for Cancer Research and Care

To achieve our goal of eliminating the suffering and death due to cancer, we must build and sustain strong research environments, support structures, collaborations, and communication channels that will enable us to quickly pursue new ideas, translate discoveries into innovative interventions, and disseminate evidence-based treatments and practices worldwide. We must nurture and maintain a cadre of scientists and health care professionals in a variety of disciplines, and we must strive to eliminate barriers to information, research opportunities, and adequate care. Therefore, NCI seeks to share its expertise and to facilitate capacity building and infrastructure development to strengthen cancer research and improve the quality of cancer care around the world. These efforts are especially important in nations that have limited resources.

The following are several examples of NCI's efforts aimed at increasing the capacity and building the infrastructure for high-quality cancer research and cancer care worldwide.

The Ireland-Northern Ireland-NCI Cancer Consortium to enhance the infrastructure for cancer research and cancer care across Ireland
In 1999, a historic memorandum of understanding was signed that established the Ireland-Northern Ireland-NCI Cancer Consortium. The primary goal of this consortium is to enhance the infrastructure for cancer research and cancer care across all of Ireland. In addition to facilitating interactions among the three represented research communities, the consortium has developed a number of joint programs covering the entire continuum of cancer.

The range of the consortium's activities can be gauged by the focus of its working groups: Scholar Exchange, Clinical Trials, Cancer Registries, Nursing, Information Technology/ Telecommunications, and Prevention. Several of these activities are discussed elsewhere in this portfolio, but one program particularly worth mentioning here is the effort to provide fellowships and training for Irish scientists and nurses at NCI's headquarters in Bethesda, Maryland (see Scientist Exchanges and Training Programs).

The Consortium's Prevention Working Group has been particularly active. In addition to participating in workshops in Ireland on topics such as "Cancer Prevention and Tobacco Control" and "Obesity and Cancer," the working group has dedicated itself to building an Ireland-wide community of prevention-oriented scientists and cancer caregivers.

A cooperative agreement between NCI and the King Hussein Cancer Center in Jordan to enhance medical sciences and improve cancer patient care in the entire Middle East region
Dr. Samir Khleif
Dr. Samir Khleif
In September 2002, the King Hussein Cancer Center (KHCC) in Amman, Jordan forged a cooperative agreement with NCI for the purpose of enhancing medical sciences and improving cancer patient care in Jordan and the entire Middle East region. In support of the agreement, Dr. Samir Khleif, a clinical oncologist at NCI, was named as KHCC Director General.

One of the notable achievements of this agreement occurred in 2004, when NCI Director Andrew von Eschenbach and U.S. Department of Health and Human Services Secretary Tommy Thompson visited KHCC to launch its TELESYNERGY® suite, which will help foster collaboration between cancer specialists, facilitate professional education and training, and permit consultation in cancer research protocols and patient care throughout Jordan and the Middle East, at selected sites in the United States, and throughout Ireland (see also A telemedicine technology program to share expert advice and diagnostic input between the NCI and Ireland to improve patient outcomes).

International Conference on Cancer in Africa
NCI supported the 5th International Conference on Cancer in Africa, which was held in Dakar, Senegal in November 2005.

The conference, hosted by the African Organization for Research and Training in Cancer, was designed to develop a research agenda for dealing with the increasing crisis of cancer in Africa. This research agenda will focus on screening, prevention, and management of high-incidence cancers, such as breast, cervical, and prostate cancer. The conference sought to establish global partnerships among oncology care givers and to address health care disparities, with a focus on early detection and cancer prevention.

The problem of tobacco-related cancers in Africa was one of the issues discussed at the conference. Participants discussed ways to combat the growing incidence of these cancers as the tobacco industry turns more to the developing world to find markets for its products.

Also discussed was the problem of how to pay for cancer care for patients who have no resources or health insurance. Funding adequate cancer care in such resource-poor environments presents monumental challenges. Early detection and cancer prevention were recommended as ways to minimize both the costs and the risks posed by cancer. In Africa, most cancer patients do not see health care providers until their disease has progressed to an advanced stage. Calls were made to encourage women to conduct breast self-examinations and to get Pap smears at least once every 2 years. Cervical cancer is the most prevalent cancer among African women, despite being the most preventable of all gynecologic cancers.

Finally, the importance of improving the availability and use of palliative care to relieve cancer symptoms and the adverse effects of treatment among African cancer patients was stressed.

Centers for AIDS Research program to establish a state-of-the-art AIDS research laboratory in Uganda
NCI, along with other institutes of the National Institutes of Health, cosponsors awards to establish and maintain Centers for AIDS Research (CFARs) at U.S. institutions that receive substantial AIDS funding from multiple NIH sources. The mission of each CFAR is to support a multidisciplinary environment that encourages collaboration across basic and clinical studies and promotes research in the prevention, detection, and treatment of HIV infection, AIDS, and AIDS-associated diseases, including cancer. Currently, there are 20 CFARs at U.S. research institutions.

One way in which the CFARs seek to accomplish their mission involves strengthening the capacity for HIV/AIDS research in developing countries. The Case Western Reserve University CFAR's activities in the African nation of Uganda serve as an example of these efforts. Building on its longstanding relationship with Makere University in Kampala, Uganda, the Case Western CFAR worked to establish the Uganda Laboratory Core in 1997. This laboratory facility created the capacity in Uganda to perform state-of-the-art immunology and virology research and to provide laboratory services for health care professionals throughout central Africa. It also provided opportunities to extend the scientific activities of the Uganda-Case Western Reserve University Research Collaboration to include studies in AIDS-related malignancies.

Expansion of the U.S.-based Comprehensive Cancer Control Leadership Institutes to serve the international community
In the last four years, the rapid growth and evolution of national cancer control planning has led to highly visible and successful initiatives by NCI's Cancer Information Service (NCI CIS) that are designed to improve public health in the United States. In these efforts, the NCI CIS joined with a U.S.-based group of experts, including the American Cancer Society, the Centers for Disease Control and Prevention, and the Intercultural Cancer Council to develop the Comprehensive Cancer Control Leadership Institutes (CCCLIs). Domestically, CCCLIs provide an opportunity for highly skilled, influential individuals in the United States to take action together to support implementation efforts for a comprehensive cancer control approach in their respective states.

With the success of the CCCLIs in the United States, the CIS and its partners began to address the need for global comprehensive cancer control planning in 2004. The main role for the CIS in these international efforts is capacity building. In September 2004, the CIS helped form a new international comprehensive cancer control group that is investigating the feasibility and the interest in an international version of the CCCLIs. The group consists of federal and non-federal partners including experts from NCI, the U.S. Centers for Disease Control and Prevention, the American Cancer Society, and the International Union Against Cancer (UICC). In 2005, the NCI CIS supported Peruvian cancer leaders in developing a cancer control plan for that nation. The first pilot of an international CCCLI workshop took place in Mexico City in June 2006, with participation from Brazil, Mexico, Peru, and Uruguay. In addition, two workshops on cancer control planning are being held at the UICC's World Cancer Congress 2006 meeting in Washington, D.C.

The Middle East Cancer Consortium
The Middle East Cancer Consortium (MECC), which was established in 1996, is a unique partnership involving the United States and the Ministries of Health of Cyprus, Egypt, Israel, Jordan, the Palestinian Authority (Gaza and the West Bank), and Turkey. One of the consortium's principal initiatives is its Cancer Registry Project, which supports the development of high-quality, population-based cancer registries in all MECC jurisdictions.

To facilitate registry training, MECC established an education program and developed a "Manual of Standards for Cancer Registration." The manual, which is now in its fourth edition (2005), defines requirements for data collection and coding that are to be followed by all MECC registries. In addition, staff from NCI's Surveillance, Epidemiology, and End Results (SEER) Program have provided assistance with training, technical support, and quality control.

The first report1 based on MECC-affiliated registry data was published in the European Journal of Cancer Prevention in 2003. This report contained the first-ever comparison of cancer incidence rates in Israel and one of its Arab neighbors, Jordan. The report had Israeli, Jordanian, and American authors, including three NCI scientists.

The first monograph from the MECC Cancer Registry Project was released in 2006. This monograph, entitled Cancer Incidence in Four Member Countries (Cyprus, Egypt, Israel, and Jordan) of the Middle East Cancer Consortium (MECC) Compared with U.S. SEER, provides information about cancer incidence for populations in Cyprus, Egypt (Gharbiah Region), Israel (Jews and Arabs), and Jordan for the period 1996-2001 in comparison with data reported by SEER for the United States. This monograph can be accessed on the Internet at http://seer.cancer.gov/publications/mecc/mecc_monograph.pdf. Alternatively, a print copy can be ordered from SEER (http://seer.cancer.gov/publications).


1 Freedman L, Barchana M, Al-Kayed S, Qasem M, Young J, Edwards B, Ries L, Roffers S, Harford J, Silberman M. A comparison of population-based cancer incidence rates in Israel and Jordan. European Journal of Cancer Prevention 12(5):359-365, 2003.

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