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AIDSinfo At-a-Glance

Issue No. 32

September 23, 2005

AIDSinfo.nih.gov is pleased to provide you with a weekly update of highlights about what has happened in the world of HIV/AIDS treatment, prevention, and research. We hope you find this encapsulated view of HIV/AIDS news useful.

 

Recommendations for Non-HIV-Specialized Providers Caring for Displaced HIV-Infected Residents from the Hurricane Disasters—

 Essential Information for Managing HIV-Infected Patients Receiving Antiretroviral Therapy

Some HIV-infected patients may have interrupted their antiretroviral therapy and other medications due to the recent hurricane disasters.  The following information provides some guidance to the general practitioners attending to the medical needs of displaced HIV-infected adult or pediatric patients who have not yet secured HIV care in the local area. 

Management of antiretroviral therapy is complex and should best be done with the assistance of specialized clinicians.  Medical consultation may also be available at specific local or regional HIV clinics or via the 24-hour NIH Medical Consultation Services at 1-866-887-2842 or the National HIV Telephone Consultation Service: at 1-800-933-3413.  For a more in-depth look at these recommendations

HIV Drug Trial Halted Due to Liver Toxicity

AIDSinfo staff attended the Treatment and Management of HIV Conference in Atlanta, Georgia, last week, where there was a lot of discussion about CCR5 inhibitors. During that same week, GlaxoSmithKline PLC announced that it had halted safety and efficacy trials of the CCR5 inhibitor aplaviroc, after 2 of the 250 treatment-naïve trial participants developed severe liver toxicity. However, studies of aplaviroc are continuing among 40 treatment-experienced participants whose virus is resistant to currently approved treatments.

Other investigational CCR5 inhibitors include maraviroc and vicriviroc. PubMed provides access to a comprehensive review of entry inhibitors, including CCR5 inhibitors.

 

ClinicalTrials.gov Info

For information about CCR5 inhibitor clinical trials go to: ClinicalTrials.gov. New HIV/AIDS trials have been added to ClinicalTrials.gov in the last 7 days.
For a list of trials click here.

 

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