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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase I Randomized Study of Topical Myristyl Nicotinate Cream on The Skin of Healthy Volunteers

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase I Prevention Active 18 and over NCI UARIZ-BIO-07-085 BIO-07-085, NCT00619060

Trial Description

Purpose:

Chemoprevention is the use of certain drugs to keep cancer from forming. The use of topical myristyl nicotinate cream may stop skin cancer from forming.

This randomized phase I trial is studying the side effects and best way to give topical myristyl nicotinate cream on the skin of healthy volunteers.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• At least 1 month since using topical medications on the skin of the hands and arms
• Forearms are not inflamed or irritated
• No history of actinic keratosis or skin cancer on the forearm
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Participants will be randomly assigned to one of two treatment groups.

Participants in both groups will apply topical myristyl nicotinate to one forearm and a topical placebo to the other forearm once a day for 4 weeks. Participants in group one will apply the drug and placebo to the opposite arms as those in group two.

All participants will also undergo blood sample collection for laboratory studies at the beginning of the study and at 2 and 4 weeks.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Arizona Cancer Center at University of Arizona Health Sciences Center

Clara Curiel, MD, Protocol chair		Ph: 520-321-7747; 800-622-2673

U.S.A.
Arizona
	Tucson
	Arizona Cancer Center at University of Arizona Health Sciences Center
		Clinical Trials Office - Arizona Cancer Center at University of Arizona Health Sciences Center	Ph:  520-626-9008

Registry Information
Official Title		A Phase I Study of Topical Myristyl Nicotinate Cream on Human Skin in Healthy Volunteers
Trial Start Date		2007-08-07
Trial Completion Date		2008-02-27 (estimated)
Registered in ClinicalTrials.gov		NCT00619060
Date Submitted to PDQ		2008-01-24
Information Last Verified		2008-03-30
NCI Grant/Contract Number		CA23074, CA27502