Periodic fever, aphthous stomatitis, pharyngitis and adenitis
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Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) is a periodic disease. 'Periodic disease' refer to a heterogeneous group of disorders characterized by short episodes of illness that regularly recur for several years alternated with healthy periods.[4]
PFAPA is characterized by high fevers lasting three to six days and recurring every 21 to 28 days, accompanied by some or all of the signs noted in its name, namely mouth sores (aphthous stomatitis), sore throat (pharyngitis), and enlarged lymph nodes (cervical adenitis). The syndrome usually occurs in children younger than five years[3] although it has been reported in children up to 13 years[2]. The syndrome is sporadic and nonhereditary.[1] The course of PFAPA can be persistent for years before spontaneous, full resolution.[5]
References
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Kurtaran H, Karadað A, Catal F, Aktaþ D. PFAPA syndrome: a rare cause of periodic fever. Turk J Pediatr. 2004;:. Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15641271&query_hl=33. March 19, 2009.
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Ovetchkine P, Bry ML, Reinert P. . Arch Pediatr. 2000;:. Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10941483&query_hl=35. March 19, 2009.
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Sadovsky R. . American Family Physician. 2003;:. Available at: http://www.aafp.org/afp/20030215/tips/25.html. March 19, 2009.
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Berlucchi M, Nicolai P. . Orphanet encyclopedia. 2004;:. Available at: http://www.orpha.net/data/patho/GB/uk-PFAPA.pdf. March 19, 2009.
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Long S.. Tonsillectomy as treatment of PFAPA syndrome. Journal of Pediatrics. 2007.
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The Merck Maual provides information on periodic fever syndromes in general. The Merck Manuals are a series of healthcare books for medical professionals and consumers.
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Orphanet is a database dedicated to information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
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The Cleveland Clinic Foundation Web site has an information page on periodic fever syndromes including PFAPA. Click on the Cleveland Clinic Foundation to view the information page.
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TheDoctorsDoctor.com web site provides additional information on PFAPA syndrome. Click on the link above to view this information page.
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PubMed is a searchable database of medical literature and lists journal articles that discuss Periodic fever, aphthous stomatitis, pharyngitis and adenitis. Click on the link to view a sample search on this topic.
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MUMS National Parent to Parent Network puts parents in touch with other parents who have children with this condition or similar symptoms.
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