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glucarpidase A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) | carboxypeptidase-G2 | | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) | Voraxaze | | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) | CPDG2 CPG2 | | ![](https://webarchive.library.unt.edu/eot2008/20090115004552im_/http://www.cancer.gov/images/spacer.gif) |
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