Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • Hemophilia, acquired
  • Acquired haemophilia

Acquired hemophilia
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Acquired hemophilia is a rare form of hemophilia in which the body makes specialized proteins called autoantibodies that attack and disable coagulation factors (proteins in the blood that assist with the clotting process).[1] The most common coagulation factor attacked is coagulation factor VIII, though other coagulation factors, including factor V and factor IX have been associated with the condition.[2] The production of autoantibodies is sometimes associated with pregnancy, immune system disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome), viral infections cancer, or allergic reactions to certain drugs.[1][2] In about half of cases, the cause of acquired hemophilia is unknown.[1] Treatment may vary from person to person.

References
  1. Hemophilia. Genetics Home Reference. March 2007 Available at: http://ghr.nlm.nih.gov/condition=hemophilia. Accessed October 15, 2008.
  2. Zeitler H, Ulrich-Merzenich G, Hess L, Konsek E, Unkrig C, Walger P, et al. . Blood. 2005;:. Available at: http://bloodjournal.hematologylibrary.org/cgi/reprint/105/6/2287. October 14, 2008.

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